Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast

• Verfasst von: Hawighorst, Hans [VerfasserIn]
• Verfasst von: Schreiber, Wolfgang [VerfasserIn]
• Verfasst von: Knopp, Michael V. [VerfasserIn]
• Verfasst von: Essig, Marco [VerfasserIn]
• Verfasst von: Engenhart, Rita [VerfasserIn]
• Verfasst von: Brix, Gunnar [VerfasserIn]
• Verfasst von: Kaick, Gerhard van [VerfasserIn]
• Titel: Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast
• Verf.angabe: Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick
• Jahr: 1996
• Umfang: 8 S.
• Fussnoten: Elektronische Reproduktion der Druck-Ausgabe 25. März 1999 ; Gesehen am 12.12.2024
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 1996
• Band/Heft Quelle: 14(1996), 10, Seite 1119-1126
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/S0730-725X(96)00241-X
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Irradiation
• Sach-SW: Magnetic resonance (MR)
• Sach-SW: Magnetization transfer (MT) technique
• Sach-SW: Malignant glioma
• Sach-SW: Radiation therapy
• K10plus-PPN: 1912174243

Abstract

The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p < .01) larger than those obtained from T1-weighted SE images (45 ± 15 cm3 vs. 33 ± 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 ± 14 compared with 30 ± 14 on SE images, representing a significant (p < .01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy.