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Status: Bibliographieeintrag

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Verfasst von:Hawighorst, Hans [VerfasserIn]   i
 Schreiber, Wolfgang [VerfasserIn]   i
 Knopp, Michael V. [VerfasserIn]   i
 Essig, Marco [VerfasserIn]   i
 Engenhart, Rita [VerfasserIn]   i
 Brix, Gunnar [VerfasserIn]   i
 Kaick, Gerhard van [VerfasserIn]   i
Titel:Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast
Verf.angabe:Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick
Jahr:1996
Umfang:8 S.
Fussnoten:Elektronische Reproduktion der Druck-Ausgabe 25. März 1999 ; Gesehen am 12.12.2024
Titel Quelle:Enthalten in: Magnetic resonance imaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:1996
Band/Heft Quelle:14(1996), 10, Seite 1119-1126
ISSN Quelle:1873-5894
Abstract:The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p < .01) larger than those obtained from T1-weighted SE images (45 ± 15 cm3 vs. 33 ± 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 ± 14 compared with 30 ± 14 on SE images, representing a significant (p < .01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy.
DOI:doi:10.1016/S0730-725X(96)00241-X
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/S0730-725X(96)00241-X
 Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X9600241X
 DOI: https://doi.org/10.1016/S0730-725X(96)00241-X
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Irradiation
 Magnetic resonance (MR)
 Magnetization transfer (MT) technique
 Malignant glioma
 Radiation therapy
K10plus-PPN:1912174243
Verknüpfungen:→ Zeitschrift

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