| Online-Ressource |
Verfasst von: | Hawighorst, Hans [VerfasserIn]  |
| Schreiber, Wolfgang [VerfasserIn]  |
| Knopp, Michael V. [VerfasserIn]  |
| Essig, Marco [VerfasserIn]  |
| Engenhart, Rita [VerfasserIn]  |
| Brix, Gunnar [VerfasserIn]  |
| Kaick, Gerhard van [VerfasserIn]  |
Titel: | Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast |
Verf.angabe: | Hans Hawighorst, Wolfgang Schreiber, Michael V. Knopp, Marco Essig, Rita Engenhart-Cabilic, Gunnar Brix, Gerhard van Kaick |
Jahr: | 1996 |
Umfang: | 8 S. |
Fussnoten: | Elektronische Reproduktion der Druck-Ausgabe 25. März 1999 ; Gesehen am 12.12.2024 |
Titel Quelle: | Enthalten in: Magnetic resonance imaging |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1982 |
Jahr Quelle: | 1996 |
Band/Heft Quelle: | 14(1996), 10, Seite 1119-1126 |
ISSN Quelle: | 1873-5894 |
Abstract: | The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p < .01) larger than those obtained from T1-weighted SE images (45 ± 15 cm3 vs. 33 ± 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 ± 14 compared with 30 ± 14 on SE images, representing a significant (p < .01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy. |
DOI: | doi:10.1016/S0730-725X(96)00241-X |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0730-725X(96)00241-X |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X9600241X |
| DOI: https://doi.org/10.1016/S0730-725X(96)00241-X |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Irradiation |
| Magnetic resonance (MR) |
| Magnetization transfer (MT) technique |
| Malignant glioma |
| Radiation therapy |
K10plus-PPN: | 1912174243 |
Verknüpfungen: | → Zeitschrift |
Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast / Hawighorst, Hans [VerfasserIn]; 1996 (Online-Ressource)