Ferritin levels on hospital admission predict hypoxic-ischemic encephalopathy in patients after out-of-hospital cardiac arrest

• Verfasst von: Nickelsen, Swantje [VerfasserIn]
• Verfasst von: Grosse Darrelmann, Eleonore [VerfasserIn]
• Verfasst von: Seidlmayer, Lea [VerfasserIn]
• Verfasst von: Fink, Katrin [VerfasserIn]
• Verfasst von: Britsch, Simone [VerfasserIn]
• Verfasst von: Dürschmied, Daniel [VerfasserIn]
• Verfasst von: Scharf, Rüdiger Eberhard [VerfasserIn]
• Verfasst von: Elsässer, Albrecht [VerfasserIn]
• Verfasst von: Helbing, Thomas [VerfasserIn]
• Titel: Ferritin levels on hospital admission predict hypoxic-ischemic encephalopathy in patients after out-of-hospital cardiac arrest
• Titelzusatz: a prospective observational single-center study
• Verf.angabe: Swantje Nickelsen, MD, Eleonore Grosse Darrelmann, MD, Lea Seidlmayer, MD, Katrin Fink, MD, Simone Britsch, MD, Daniel Duerschmied, MD, Ruediger E. Scharf, MD, Albrecht Elsaesser, MD, and Thomas Helbing, MD
• E-Jahr: 2024
• Jahr: November 2024
• Umfang: 11 S.
• Fussnoten: Erstmals online veröffentlicht: 15. Mai 2024 ; Gesehen am 17.12.2024
• Titel Quelle: Enthalten in: Journal of intensive care medicine
• Ort Quelle: Thousand Oaks, Calif. [u.a.] : Sage Science Press, 1986
• Jahr Quelle: 2024
• Band/Heft Quelle: 39(2024), 11 vom: Nov., Seite 1120-1130
• ISSN Quelle: 1525-1489
• DOI: doi:10.1177/08850666241252602
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1912761920

Abstract

Aim - Out-of-hospital cardiac arrest (OHCA) is a major health concern in Western societies. Poor outcome after OHCA is determined by the extent of hypoxic-ischemic encephalopathy (HIE). Dysregulation of iron metabolism has prognostic relevance in patients with ischemic stroke and sepsis. The aim of this study was to determine whether serum iron parameters help to estimate outcomes after OHCA. - Methods - In this prospective single-center study, 70 adult OHCA patients were analyzed. Serum ferritin, iron, transferrin (TRF), and TRF saturation (TRFS) were measured in blood samples drawn on day 0 (admission), day 2, day 4, and 6 months after the return of spontaneous circulation (ROSC). The association of 4 iron parameters with in-hospital mortality, neurological outcome (cerebral performance category [CPC]), and HIE was investigated by receiver operating characteristics and multivariate regression analyses. - Results - OHCA subjects displayed significantly increased serum ferritin levels on day 0 and lowered iron, TRF, and TRFS on days 2 and 4 after ROSC, as compared to concentrations measured at a 6-month follow-up. Iron parameters were not associated with in-hospital mortality or neurological outcomes according to the CPC. Ferritin on admission was an independent predictor of features of HIE on cranial computed tomography and death due to HIE. - Conclusion - OHCA is associated with alterations in iron metabolism that persist for several days after ROSC. Ferritin on admission can help to predict HIE.