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Verfasst von:Reichert, Simon [VerfasserIn]   i
 Schepkin, Victor [VerfasserIn]   i
 Kleimaier, Dennis [VerfasserIn]   i
 Zöllner, Frank G. [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
Titel:Comparison of triple quantum (TQ) TPPI and inversion recovery TQ TPPI pulse sequences at 9.4 and 21.1 T
Verf.angabe:Simon Reichert, Victor Schepkin, Dennis Kleimaier, Frank G. Zoellner, Lothar R. Schad
E-Jahr:2024
Jahr:May 2024
Umfang:15 S.
Fussnoten:Online veröffentlicht: 23. Januar 2024 ; Gesehen am 23.08.2024
Titel Quelle:Enthalten in: NMR in biomedicine
Ort Quelle:New York, NY : Wiley, 1988
Jahr Quelle:2024
Band/Heft Quelle:37(2024), 5, Artikel-ID e5106, Seite 1-15
ISSN Quelle:1099-1492
Abstract:Purpose: Both sodium T-1 triple quantum (TQ) signal and T-1 relaxation pathways have a unique sensitivity to the sodium molecular environment. In this study an inversion recovery time proportional phase increment (IRTQTPPI) pulse sequence was investigated for simultaneous and reliable quantification of sodium TQ signal and bi-exponential T-1 relaxation times.Methods: The IRTQTPPI sequence combines inversion recovery TQ filtering and time proportional phase increment. The reliable and reproducible results were achieved by the pulse sequence optimized in three ways: (1) optimization of the nonlinear fit for the determination of both T-1-TQ signal and T-1 relaxation times; (2) suppression of unwanted signals by assessment of four different phase cycles; (3) nonlinear sampling during evolution time for optimal scan time without any compromises in fit accuracy. The relaxation times T-1 and T-2 and the TQ signals from IRTQTPPI and TQTPPI were compared between 9.4 and 21.1 T. The motional environment of the sodium nuclei was evaluated by calculation of correlation times and nuclear quadrupole interaction strengths.Results: Reliable measurements of the T-1-TQ signals and T-1 bi-exponential relaxation times were demonstrated. The fit parameters for all four phase cycles were in good agreement with one another, with a negligible influence of unwanted signals. The agar samples yielded normalized T-1-TQ signals from 3% to 16% relative to single quantum (SQ) signals at magnetic fields of both 9.4 and 21.1 T. In comparison, the normalized T-2-TQ signal was in the range 15%-35%. The TQ/SQ signal ratio was decreased at 21.1 T as compared with 9.4 T for both T-1 and T-2 relaxation pathways. The bi-exponential T-1 relaxation time separation ranged from 15 to 18 ms at 9.4 T and 15 to 21 ms at 21.1 T. The T-2 relaxation time separation was larger, ranging from 28 to 35 ms at 9.4 T and 37 to 40 ms at 21.1 T.Conclusion: The IRTQTPPI sequence, while providing a less intensive TQ signal than TQTPPI, allows a simultaneous and reliable quantification of both the T-1-TQ signal and T-1 relaxation times. The unique sensitivities of the T-1 and T-2 relaxation pathways to different types of molecular motion provide a deeper understanding of the sodium MR environment.
DOI:doi:10.1002/nbm.5106
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1002/nbm.5106
 kostenfrei: Volltext: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/nbm.5106
 DOI: https://doi.org/10.1002/nbm.5106
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CHEMOTHERAPEUTIC RESPONSE
 COHERENCE DYNAMICS
 FILTERED NA-23 NMR
 IN-VIVO
 INTRACELLULAR NA CONTENT
 inversion recovery
 multi-quantum
 Na-23 (sodium) MRI
 NUCLEAR-MAGNETIC-RESONANCE
 PERFUSED RAT-HEART
 SINGLE-QUANTUM
 SODIUM MRI
 T-1 and T-2 relaxation
 THERMAL RELAXATION
 triple quantum (TQ)
K10plus-PPN:189941777X
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