| |  Online-Ressource |
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| Verfasst von: | Schöttler, Jochen [VerfasserIn]  |
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| | Brohm, Kathrin [VerfasserIn] |
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| | Mindt, Sonani [VerfasserIn] |
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| | Jäger, Evelyn [VerfasserIn] |
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| | Hahn, Bianka [VerfasserIn] |
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| | Fuderer, Tanja [VerfasserIn] |
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| | Lindner, Holger A. [VerfasserIn] |
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| | Schneider-Lindner, Verena [VerfasserIn] |
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| | Krebs, Jörg [VerfasserIn] |
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| | Neumaier, Michael [VerfasserIn] |
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| | Thiel, Manfred [VerfasserIn] |
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| | Centner, Franz-Simon [VerfasserIn] |
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| Titel: | Mortality prediction by kinetic parameters of lactate and s-adenosylhomocysteine in a cohort of critically Ill patients |
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| Verf.angabe: | Jochen J. Schoettler, Kathrin Brohm, Sonani Mindt, Evelyn Jäger, Bianka Hahn, Tanja Fuderer, Holger A. Lindner, Verena Schneider-Lindner, Joerg Krebs, Michael Neumaier, Manfred Thiel and Franz-Simon Centner |
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| E-Jahr: | 2024 |
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| Jahr: | 9 June 2024 |
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| Umfang: | 17 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 20.01.2025 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 25(2024), 12, Artikel-ID 6391, Seite 1-17 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Tissue hypoxia is associated with the development of organ dysfunction and death in critically ill patients commonly captured using blood lactate. The kinetic parameters of serial lactate evaluations are superior at predicting mortality compared with single values. S-adenosylhomocysteine (SAH), which is also associated with hypoxia, was recently established as a useful predictor of septic organ dysfunction and death. We evaluated the performance of kinetic SAH parameters for mortality prediction compared with lactate parameters in a cohort of critically ill patients. For lactate and SAH, maxima and means as well as the normalized area scores were calculated for two periods: the first 24 h and the total study period of up to five days following ICU admission. Their performance in predicting in-hospital mortality were compared in 99 patients. All evaluated parameters of lactate and SAH were significantly higher in non-survivors compared with survivors. In univariate analysis, the predictive power for mortality of SAH was higher compared with lactate in all forms of application. Multivariable models containing SAH parameters demonstrated higher predictive values for mortality than models based on lactate parameters. The optimal models for mortality prediction incorporated both lactate and SAH parameters. Compared with lactate, SAH displayed stronger predictive power for mortality in static and dynamic application in critically ill patients. |
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| DOI: | doi:10.3390/ijms25126391 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms25126391 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/25/12/6391 |
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| | DOI: https://doi.org/10.3390/ijms25126391 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | critically ill patients |
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| | lactate |
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| | mortality prediction |
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| | organ dysfunction |
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| | s-adenosylhomocysteine |
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| K10plus-PPN: | 1915112338 |
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| Verknüpfungen: | → Zeitschrift |
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Mortality prediction by kinetic parameters of lactate and s-adenosylhomocysteine in a cohort of critically Ill patients / Schöttler, Jochen [VerfasserIn]; 9 June 2024 (Online-Ressource)
