Innate-like T cells in liver disease

• Verfasst von: Yang, Albert Ying-Po [VerfasserIn]
• Verfasst von: Wistuba-Hamprecht, Kilian [VerfasserIn]
• Verfasst von: Greten, Tim F. [VerfasserIn]
• Verfasst von: Ruf, Benjamin [VerfasserIn]
• Titel: Innate-like T cells in liver disease
• Verf.angabe: Albert Ying-Po Yang, Kilian Wistuba-Hamprecht, Tim F. Greten, and Benjamin Ruf
• E-Jahr: 2024
• Jahr: July 2024
• Umfang: 14 S.
• Illustrationen: Illustrationen
• Fussnoten: Online verfügbar: 14. Juni 2024, Artikelversion: 11. Juli 2024 ; Gesehen am 30.01.2025
• Titel Quelle: Enthalten in: Trends in immunology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 2001
• Jahr Quelle: 2024
• Band/Heft Quelle: 45(2024), 7 vom: Juli, Seite 535-548
• ISSN Quelle: 1471-4981
• DOI: doi:10.1016/j.it.2024.05.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ILTCs
• Sach-SW: liver diseases
• Sach-SW: MAIT
• Sach-SW: NKT
• Sach-SW: γδ T cells
• K10plus-PPN: 1916041795

Abstract

Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis. This review explores the involvement of different ILTC subsets in liver diseases. We explore the mechanisms underlying the pro- and anti-inflammatory effector functions of ILTCs in a context-dependent manner. We highlight latest findings regarding the dynamic interplay between ILTC functional subsets and other immune and parenchymal cells which may inform candidate immunomodulatory strategies to achieve improved clinical outcomes in liver diseases. We present new insights into how distinct gene expression programs in hepatic ILTCs are induced, maintained, and reprogrammed in a context- and disease stage-dependent manner.