| |  Online-Ressource |
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| Verfasst von: | Hegazy, Ahmed Nabil [VerfasserIn]  |
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| | Peine, Caroline [VerfasserIn] |
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| | Niesen, Dominik [VerfasserIn] |
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| | Panse, Isabel [VerfasserIn] |
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| | Vainshtein, Yevhen [VerfasserIn] |
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| | Kommer, Christoph [VerfasserIn] |
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| | Zhang, Qin [VerfasserIn] |
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| | Brunner, Tobias M. [VerfasserIn] |
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| | Peine, Michael [VerfasserIn] |
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| | Fröhlich, Anja [VerfasserIn] |
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| | Ishaque, Naveed [VerfasserIn] |
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| | Marek, Roman M. [VerfasserIn] |
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| | Zhu, Jinfang [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| | Löhning, Max [VerfasserIn] |
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| Titel: | Plasticity and lineage commitment of individual TH1 cells are determined by stable T-bet expression quantities |
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| Verf.angabe: | Ahmed N. Hegazy, Caroline Peine, Dominik Niesen, Isabel Panse, Yevhen Vainshtein, Christoph Kommer, Qin Zhang, Tobias M. Brunner, Michael Peine, Anja Fröhlich, Naveed Ishaque, Roman M. Marek, Jinfang Zhu, Thomas Höfer, Max Löhning |
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| E-Jahr: | 2024 |
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| Jahr: | June 7, 2024 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 14.02.2025 ; Im Titel ist "H" tiefgestellt |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 10(2024), 23 vom: Juni, Artikel-ID eadk2693, Seite 1-15 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | T helper 1 (TH1) cell identity is defined by the expression of the lineage-specifying transcription factor T-bet. Here, we examine the influence of T-bet expression heterogeneity on subset plasticity by leveraging cell sorting of distinct in vivo-differentiated TH1 cells based on their quantitative expression of T-bet and interferon-γ. Heterogeneous T-bet expression states were regulated by virus-induced type I interferons and were stably maintained even after secondary viral infection. Exposed to alternative differentiation signals, the sorted subpopulations exhibited graded levels of plasticity, particularly toward the TH2 lineage: T-bet quantities were inversely correlated with the ability to express the TH2 lineage-specifying transcription factor GATA-3 and TH2 cytokines. Reprogramed TH1 cells acquired graded mixed TH1 + TH2 phenotypes with a hybrid epigenetic landscape. Continuous presence of T-bet in differentiated TH1 cells was essential to ensure TH1 cell stability. Thus, innate cytokine signals regulate TH1 cell plasticity via an individual cell-intrinsic rheostat to enable T cell subset adaptation to subsequent challenges. |
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| DOI: | doi:10.1126/sciadv.adk2693 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1126/sciadv.adk2693 |
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| | DOI: https://doi.org/10.1126/sciadv.adk2693 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Cell Differentiation |
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| | Cell Lineage |
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| | Cell Plasticity |
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| | Cytokines |
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| | GATA3 Transcription Factor |
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| | Gene Expression Regulation |
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| | Interferon-gamma |
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| | Mice |
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| | T-bet Transcription Factor |
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| | T-Box Domain Proteins |
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| | Th1 Cells |
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| | Th2 Cells |
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| K10plus-PPN: | 1917298064 |
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| Verknüpfungen: | → Zeitschrift |
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Plasticity and lineage commitment of individual TH1 cells are determined by stable T-bet expression quantities / Hegazy, Ahmed Nabil [VerfasserIn]; June 7, 2024 (Online-Ressource)
