| |  Online-Ressource |
|---|
| Verfasst von: | Cendrowski, Jaroslaw [VerfasserIn]  |
|---|
| | Wrobel, Marta [VerfasserIn] |
|---|
| | Mazur, Michal [VerfasserIn] |
|---|
| | Jary, Bartosz [VerfasserIn] |
|---|
| | Maurya, Ranjana [VerfasserIn] |
|---|
| | Wang, Surui [VerfasserIn] |
|---|
| | Korostynski, Michal [VerfasserIn] |
|---|
| | Dziewulska, Anna [VerfasserIn] |
|---|
| | Rohm, Maria [VerfasserIn] |
|---|
| | Kuropka, Patryk [VerfasserIn] |
|---|
| | Pudelko-Malik, Natalia [VerfasserIn] |
|---|
| | Mlynarz, Piotr [VerfasserIn] |
|---|
| | Dobrzyn, Agnieszka [VerfasserIn] |
|---|
| | Zeigerer, Anja [VerfasserIn] |
|---|
| | Miaczynska, Marta [VerfasserIn] |
|---|
| Titel: | NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency |
|---|
| Verf.angabe: | Jaroslaw Cendrowski, Marta Wrobel, Michal Mazur, Bartosz Jary, Ranjana Maurya, Surui Wang, Michal Korostynski, Anna Dziewulska, Maria Rohm, Patryk Kuropka, Natalia Pudelko-Malik, Piotr Mlynarz, Agnieszka Dobrzyn, Anja Zeigerer, Marta Miaczynska |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | 19 November 2024 |
|---|
| Umfang: | 27 S. |
|---|
| Fussnoten: | Gesehen am 07.04.2025 ; Im Titel ist "NFκB" mit einem griechischen Buchstaben geschrieben |
|---|
| Titel Quelle: | Enthalten in: Cellular and molecular life sciences |
|---|
| Ort Quelle: | Cham (ZG) : Springer International Publishing AG, 1997 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 81(2024), 1, Artikel-ID 458, Seite 1-27 |
|---|
| ISSN Quelle: | 1420-9071 |
|---|
| Abstract: | Endosomal Sorting Complexes Required for Transport (ESCRTs) are crucial for delivering membrane receptors or intracellular organelles for lysosomal degradation which provides the cell with lysosome-derived nutrients. Yet, how ESCRT dysfunction affects cell metabolism remained elusive. To address this, we analyzed transcriptomes of cells lacking TSG101 or VPS28 proteins, components of ESCRT-I subcomplex. ESCRT-I deficiency reduced the expression of genes encoding enzymes involved in oxidation of fatty acids and amino acids, such as branched-chain amino acids, and increased the expression of genes encoding glycolytic enzymes. The changes in metabolic gene expression were associated with Warburg effect-like metabolic reprogramming that included intracellular accumulation of lipids, increased glucose/glutamine consumption and lactate production. Moreover, depletion of ESCRT-I components led to expansion of the ER and accumulation of small mitochondria, most of which retained proper potential and performed ATP-linked respiration. Mechanistically, the observed transcriptional reprogramming towards glycolysis in the absence of ESCRT-I occurred due to activation of the canonical NFκB and JNK signaling pathways and at least in part by perturbed lysosomal degradation. We propose that by activating the stress signaling pathways ESCRT-I deficiency leads to preferential usage of extracellular nutrients, like glucose and glutamine, for energy production instead of lysosome-derived nutrients, such as fatty acids and branched-chain amino acids. |
|---|
| DOI: | doi:10.1007/s00018-024-05490-y |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1007/s00018-024-05490-y |
|---|
| | kostenfrei: Volltext: http://link.springer.com/article/10.1007/s00018-024-05490-y |
|---|
| | DOI: https://doi.org/10.1007/s00018-024-05490-y |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1921674679 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency / Cendrowski, Jaroslaw [VerfasserIn]; 19 November 2024 (Online-Ressource)
