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| Verfasst von: | Cordero, Julio [VerfasserIn]  |
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| | Swaminathan, Guruprasadh [VerfasserIn] |
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| | Rogel-Ayala, Diana G. [VerfasserIn] |
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| | Rubio Nava, Karla Maria [VerfasserIn] |
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| | Elsherbiny, Adel [VerfasserIn] |
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| | Mahmood, Samina [VerfasserIn] |
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| | Szymański, Witold [VerfasserIn] |
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| | Graumann, Johannes [VerfasserIn] |
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| | Braun, Thomas [VerfasserIn] |
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| | Günther, Stefan [VerfasserIn] |
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| | Dobreva, Gergana [VerfasserIn] |
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| | Barreto, Guillermo [VerfasserIn] |
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| Titel: | Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription |
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| Verf.angabe: | Julio Cordero, Guruprasadh Swaminathan, Diana G. Rogel-Ayala, Karla Rubio, Adel Elsherbiny, Samina Mahmood, Witold Szymanski, Johannes Graumann, Thomas Braun, Stefan Günther, Gergana Dobreva and Guillermo Barreto |
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| E-Jahr: | 2024 |
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| Jahr: | 20 December 2024 |
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| Umfang: | 21 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Im Titel ist "TGF-β-induced transcription" mit einem griechischen Buchstaben geschrieben ; Gesehen am 07.04.2025 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 10711, Seite 1-21 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | The dynamics of three-dimensional (3D) genome organization are essential to transcriptional regulation. While enhancers regulate spatiotemporal gene expression, chromatin looping is a means for enhancer-promoter interactions yielding cell-type-specific gene expression. Further, non-canonical DNA secondary structures, such as G-quadruplexes (G4s), are related to increased gene expression. However, the role of G4s in promoter-distal regulatory elements, such as super-enhancers (SE), and in chromatin looping has remained elusive. Here we show that mature microRNA 9 (miR-9) is enriched at promoters and SE of genes that are inducible by transforming growth factor beta 1 (TGFB1) signaling. Moreover, we find that miR-9 is required for formation of G4s, promoter-super-enhancer looping and broad domains of the euchromatin histone mark H3K4me3 at TGFB1-responsive genes. Our study places miR-9 in the same functional context with G4s and promoter-enhancer interactions during 3D genome organization and transcriptional activation induced by TGFB1 signaling, a critical signaling pathway in cancer and fibrosis. |
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| DOI: | doi:10.1038/s41467-024-54740-x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-024-54740-x |
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| | Volltext: http://www.nature.com/articles/s41467-024-54740-x |
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| | DOI: https://doi.org/10.1038/s41467-024-54740-x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chromatin structure |
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| | Epigenomics |
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| | Growth factor signalling |
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| | Histone post-translational modifications |
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| | Transcription |
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| K10plus-PPN: | 1921676760 |
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| Verknüpfungen: | → Zeitschrift |
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Nuclear microRNA 9 mediates G-quadruplex formation and 3D genome organization during TGF-β-induced transcription / Cordero, Julio [VerfasserIn]; 20 December 2024 (Online-Ressource)
