Potassium levels and short-term outcomes in heart failure with mildly reduced ejection fraction

• Verfasst von: Reinhardt, Marielen [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Verfasst von: Weidner, Kathrin [VerfasserIn]
• Verfasst von: Ayasse, Niklas [VerfasserIn]
• Verfasst von: Lau, Felix [VerfasserIn]
• Verfasst von: Schmitt, Alexander [VerfasserIn]
• Verfasst von: Abel, Noah [VerfasserIn]
• Verfasst von: Dudda, Jonas [VerfasserIn]
• Verfasst von: Bertsch, Thomas [VerfasserIn]
• Verfasst von: Dürschmied, Daniel [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Schupp, Tobias [VerfasserIn]
• Titel: Potassium levels and short-term outcomes in heart failure with mildly reduced ejection fraction
• Verf.angabe: Marielen Reinhardt, Michael Behnes, Kathrin Weidner, Niklas Ayasse, Felix Lau, Alexander Schmitt, Noah Abel, Jonas Dudda, Thomas Bertsch, Daniel Duerschmied, Ibrahim Akin, Tobias Schupp
• E-Jahr: 2025
• Jahr: 15 February 2025
• Umfang: 8 S.
• Illustrationen: Diagramme
• Fussnoten: Online verfügbar: 3. Dezember 2024, Artikelversion: 12. Dezember 2024 ; Gesehen am 29.04.2025
• Titel Quelle: Enthalten in: International journal of cardiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1981
• Jahr Quelle: 2025
• Band/Heft Quelle: 421(2025) vom: Feb., Artikel-ID 132878, Seite 1-8
• ISSN Quelle: 1874-1754
• DOI: doi:10.1016/j.ijcard.2024.132878
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Heart failure with mildly reduced ejection fraction
• Sach-SW: HFmrEF
• Sach-SW: Hyperkalemia
• Sach-SW: Hypokalemia
• Sach-SW: Mortality
• Sach-SW: Potassium
• K10plus-PPN: 1923875787

Abstract

Objective - The study investigates the prognostic impact of dyskalemias in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). - Background - Although dyskalemias represent a common complication in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF), data concerning the prevalence and prognostic impact of dyskalemias in HFmrEF is limited. - Methods - Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022. The prognostic impact of potassium levels was assessed comparing patients with potassium levels > 3.3 to ≤4.5 mmol/L, ≤3.3 mmol/L and > 4.5 mmol/L. The primary endpoint was all-cause mortality at 30 days. - Results - 2079 patients with HFmrEF and potassium measurement were included (median potassium level: 4.4 mmol/L; mean 4.2 mmol/L). 84 % of patients hospitalized with HFmrEF presented with potassium levels in the norm range, 8 % with hypokalemia and 8 % with hyperkalemia, respectively. The risk of all-cause mortality at 30 days was higher in patients with hyperkalemia compared to patients with normokalemia (7 % vs 4 %; log rank p = 0.026), whereas the presence of hypokalemia (6 %; log rank p = 0.075) was not significantly associated with the risk of 30-days all-cause mortality. Compared to patients with normokalemia, the presence of hyperkalemia was still associated with an increased risk of 30-day all-cause mortality within a multivariable Cox regression analysis (HR = 2.002; 95 % CI 1.004-3.992; p = 0.049). - Conclusion - In patients hospitalized with HFmrEF, hyperkalemia - but not hypokalemia - was independently associated with an increased risk of all-cause mortality at 30 days.