| |  Online-Ressource |
|---|
| Verfasst von: | Stark, Konstantin [VerfasserIn]  |
|---|
| | Kilani, Badr [VerfasserIn] |
|---|
| | Stockhausen, Sven [VerfasserIn] |
|---|
| | Busse, Johanna [VerfasserIn] |
|---|
| | Schubert, Irene [VerfasserIn] |
|---|
| | Tran, Thuy-Duong [VerfasserIn] |
|---|
| | Gaertner, Florian [VerfasserIn] |
|---|
| | Leunig, Alexander [VerfasserIn] |
|---|
| | Pekayvaz, Kami [VerfasserIn] |
|---|
| | Nicolai, Leo [VerfasserIn] |
|---|
| | Fumagalli, Valeria [VerfasserIn] |
|---|
| | Stermann, Julia [VerfasserIn] |
|---|
| | Stephan, Felix [VerfasserIn] |
|---|
| | David, Christian [VerfasserIn] |
|---|
| | Müller, Martin B. [VerfasserIn] |
|---|
| | Heyman, Birgitta [VerfasserIn] |
|---|
| | Lux, Anja [VerfasserIn] |
|---|
| | da Palma Guerreiro, Alexandra [VerfasserIn] |
|---|
| | Frenzel, Lukas P. [VerfasserIn] |
|---|
| | Schmidt, Christoph Q. [VerfasserIn] |
|---|
| | Dopler, Arthur [VerfasserIn] |
|---|
| | Moser, Markus [VerfasserIn] |
|---|
| | Chandraratne, Sue [VerfasserIn] |
|---|
| | von Brühl, Marie-Luise [VerfasserIn] |
|---|
| | Lorenz, Michael [VerfasserIn] |
|---|
| | Korff, Thomas [VerfasserIn] |
|---|
| | Rudelius, Martina [VerfasserIn] |
|---|
| | Popp, Oliver [VerfasserIn] |
|---|
| | Kirchner, Marieluise [VerfasserIn] |
|---|
| | Mertins, Philipp [VerfasserIn] |
|---|
| | Nimmerjahn, Falk [VerfasserIn] |
|---|
| | Iannacone, Matteo [VerfasserIn] |
|---|
| | Sperandio, Markus [VerfasserIn] |
|---|
| | Engelmann, Bernd [VerfasserIn] |
|---|
| | Verschoor, Admar [VerfasserIn] |
|---|
| | Maßberg, Steffen [VerfasserIn] |
|---|
| Titel: | Antibodies and complement are key drivers of thrombosis |
|---|
| Verf.angabe: | Konstantin Stark, Badr Kilani, Sven Stockhausen, Johanna Busse, Irene Schubert, Thuy-Duong Tran, Florian Gaertner, Alexander Leunig, Kami Pekayvaz, Leo Nicolai, Valeria Fumagalli, Julia Stermann, Felix Stephan, Christian David, Martin B. Müller, Birgitta Heyman, Anja Lux, Alexandra da Palma Guerreiro, Lukas P. Frenzel, Christoph Q. Schmidt, Arthur Dopler, Markus Moser, Sue Chandraratne, Marie-Luise von Brühl, Michael Lorenz, Thomas Korff, Martina Rudelius, Oliver Popp, Marieluise Kirchner, Philipp Mertins, Falk Nimmerjahn, Matteo Iannacone, Markus Sperandio, Bernd Engelmann, Admar Verschoor, and Steffen Massberg |
|---|
| E-Jahr: | 2024 |
|---|
| Jahr: | September 10, 2024 |
|---|
| Umfang: | 28 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Gesehen am 04.06.2025 |
|---|
| Titel Quelle: | Enthalten in: Immunity |
|---|
| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1994 |
|---|
| Jahr Quelle: | 2024 |
|---|
| Band/Heft Quelle: | 57(2024), 9, Artikel-ID 2140-2156.e10, Seite 2140-2156.e10-1-2140-2156.e10-28 |
|---|
| ISSN Quelle: | 1097-4180 |
|---|
| Abstract: | Venous thromboembolism (VTE) is a common, deadly disease with an increasing incidence despite preventive efforts. Clinical observations have associated elevated antibody concentrations or antibody-based therapies with thrombotic events. However, how antibodies contribute to thrombosis is unknown. Here, we show that reduced blood flow enabled immunoglobulin M (IgM) to bind to FcμR and the polymeric immunoglobulin receptor (pIgR), initiating endothelial activation and platelet recruitment. Subsequently, the procoagulant surface of activated platelets accommodated antigen- and FcγR-independent IgG deposition. This leads to classical complement activation, setting in motion a prothrombotic vicious circle. Key elements of this mechanism were present in humans in the setting of venous stasis as well as in the dysregulated immunothrombosis of COVID-19. This antibody-driven thrombosis can be prevented by pharmacologically targeting complement. Hence, our results uncover antibodies as previously unrecognized central regulators of thrombosis. These findings carry relevance for therapeutic application of antibodies and open innovative avenues to target thrombosis without compromising hemostasis. |
|---|
| DOI: | doi:10.1016/j.immuni.2024.08.007 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.immuni.2024.08.007 |
|---|
| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S1074761324004060 |
|---|
| | DOI: https://doi.org/10.1016/j.immuni.2024.08.007 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | antibodies |
|---|
| | complement |
|---|
| | COVID-19 |
|---|
| | endothelial cells |
|---|
| | Fc-receptors |
|---|
| | neutrophil extracellular traps |
|---|
| | neutrophils |
|---|
| | platelets |
|---|
| | thrombosis |
|---|
| | venous thromboembolism |
|---|
| K10plus-PPN: | 1927448301 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Antibodies and complement are key drivers of thrombosis / Stark, Konstantin [VerfasserIn]; September 10, 2024 (Online-Ressource)
