Transcutaneous slowly depolarizing currents elicit pruritus in patients with atopic dermatitis

• Verfasst von: Rukwied, Roman [VerfasserIn]
• Verfasst von: Schnakenberg, Mark [VerfasserIn]
• Verfasst von: Solinski, Hans Jürgen [VerfasserIn]
• Verfasst von: Schmelz, Martin [VerfasserIn]
• Verfasst von: Weisshaar, Elke [VerfasserIn]
• Titel: Transcutaneous slowly depolarizing currents elicit pruritus in patients with atopic dermatitis
• Verf.angabe: Roman Rukwied, Mark Schnakenberg, Hans Jürgen Solinkski, Martin Schmelz and Elke Weisshaar
• E-Jahr: 2020
• Jahr: October 2020
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 06.06.2025
• Titel Quelle: Enthalten in: Acta dermato-venereologica
• Ort Quelle: Uppsala : Acta Dermato-Venereologica, 1921
• Jahr Quelle: 2020
• Band/Heft Quelle: 100(2020), 17 vom: Okt., Artikel-ID adv00302, Seite 1-6
• ISSN Quelle: 1651-2057
• DOI: doi:10.2340/00015555-3658
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: C-nociceptor
• Sach-SW: itch
• Sach-SW: transcutaneous electrical stimulation
• K10plus-PPN: 1927755794

Abstract

Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients with atopic dermatitis. C-nociceptor-specific electrical stimu?lation was applied to areas of eczema-affected and non-affected skin in 26 patients with atopic dermatitis. Single half-sine wave pulses (500 ms, 0.2?1 mA) induced itch in 9 patients in eczema-affected areas of the skin (numerical rating scale 5???1), but pain in control skin (numerical rating scale 6???1).Sinusoidal stimuli (4 Hz, 10 pulses, 0.025?0.4 mA) evoked itch in only 3 patients in eczema-affected areas of the skin but on delivering pulses for one minute (0.05?0.2 mA) 48% of the patients (n=?12) reported itch with numerical rating scale 4???1 in areas of eczema-affected skin. The number of patients reporting itch in eczema-affected areas of the skin increased with longer stimulation (p?