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| Verfasst von: | Singer, Susanne [VerfasserIn]  |
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| | Hammerlid, Eva [VerfasserIn] |
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| | Tomaszewska, Iwona M. [VerfasserIn] |
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| | Amdal, Cecilie D. [VerfasserIn] |
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| | Herlofson, Bente B. [VerfasserIn] |
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| | Santos, Marcos [VerfasserIn] |
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| | Castro Silva, Joaquim [VerfasserIn] |
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| | Mehanna, Hisham [VerfasserIn] |
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| | Fullerton, Amy [VerfasserIn] |
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| | Young, Teresa [VerfasserIn] |
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| | Fernandez Gonzalez, Loreto [VerfasserIn] |
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| | Inhestern, Johanna [VerfasserIn] |
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| | Pinto, Monica [VerfasserIn] |
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| | Arraras, Juan I. [VerfasserIn] |
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| | Yarom, Noam [VerfasserIn] |
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| | Bonomo, Pierluigi [VerfasserIn] |
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| | Baumann, Ingo [VerfasserIn] |
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| | Galalae, Razvan [VerfasserIn] |
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| | Nicolatou-Galitis, Ourania [VerfasserIn] |
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| | Kiyota, Naomi [VerfasserIn] |
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| | Raber-Durlacher, Judith [VerfasserIn] |
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| | Salem, Dina [VerfasserIn] |
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| | Fabian, Alexander [VerfasserIn] |
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| | Boehm, Andreas [VerfasserIn] |
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| | Krejovic-Trivic, Sanja [VerfasserIn] |
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| | Chie, Wei-Chu [VerfasserIn] |
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| | Taylor, Katherine J. [VerfasserIn] |
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| | Sherman, Allen C. [VerfasserIn] |
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| | Licitra, Lisa [VerfasserIn] |
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| | Machiels, Jean-Pascal [VerfasserIn] |
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| | Bjordal, Kristin [VerfasserIn] |
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| Titel: | The european organisation for research and treatment of cancer head and neck cancer module (EORTC QLQ-HN43) |
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| Titelzusatz: | estimates for minimal important difference and minimal important change |
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| Verf.angabe: | Susanne Singer, Eva Hammerlid, Iwona M. Tomaszewska, Cecilie D. Amdal, Bente B. Herlofson, Marcos Santos, Joaquim Castro Silva, Hisham Mehanna, Amy Fullerton, Teresa Young, Loreto Fernandez Gonzalez, Johanna Inhestern, Monica Pinto, Juan I. Arraras, Noam Yarom, Pierluigi Bonomo, Ingo Baumann, Razvan Galalae, Ourania Nicolatou-Galitis, Naomi Kiyota, Judith Raber-Durlacher, Dina Salem, Alexander Fabian, Andreas Boehm, Sanja Krejovic-Trivic, Wei-Chu Chie, Katherine J. Taylor, Allen C. Sherman, Lisa Licitra, Jean-Pascal Machiels, Kristin Bjordal, on behalf of the EORTC Quality of Life Group and the EORTC Head and Neck Cancer Group |
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| E-Jahr: | 2024 |
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| Jahr: | November 2024 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 9. Oktober 2024, Artikelversion: 13. Oktober 2024 ; Gesehen am 11.06.2025 |
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| Titel Quelle: | Enthalten in: European journal of cancer |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 212(2024) vom: Nov., Artikel-ID 115062, Seite 1-11 |
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| ISSN Quelle: | 1879-0852 |
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| Abstract: | Introduction - Minimal important change estimates (MIC) are useful for interpreting results of clinical research with quality of life (QoL) as an endpoint. For the European Organisation for Research and Treatment of Cancer head and neck cancer module, the EORTC QLQ-HN43, no such thresholds are established. - Methods - Head and neck cancer patients under active treatment (n = 503) from 15 countries completed the EORTC QLQ-HN43 three times (t1: before treatment, t2: three months after t1, t3: six months after t1). A subgroup completed a Subjective Significance Questionnaire (SSQ), indicating experienced change from the previous time point in four QoL domains. QoL was assumed to deteriorate after t1 and improve again until t3. The MIC was established using the average of mean differences in SSQ groups (MICmean) and estimates based on logistic regressions (MICpredict). Additionally, minimal detectable changes (MDC) were computed using 0.5 standard deviation and standard error of the mean. - Results - For swallowing, speech, dry mouth, and global QoL, the MIC for deterioration were 13, 14, 26, and 10 respectively. The MIC for improvement were 8 (swallowing), 6 (dry mouth), and 5 (global QoL); no MIC for speech improvement can be presented because of insufficient correlation between change score and anchor. The MDC estimates for deterioration were 15, 14, 15, and 11. For improvement, the MDC estimates were 13, 14, 14, and 11. - Conclusions - Our results underline that no single MIC or MDC can be applied to all EORTC QLQ-HN43 scales, and that the MIC for deterioration seems larger than those for improvement. |
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| DOI: | doi:10.1016/j.ejca.2024.115062 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.ejca.2024.115062 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0959804924010281 |
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| | DOI: https://doi.org/10.1016/j.ejca.2024.115062 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Clinical significance |
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| | EORTC QLQ-C30 |
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| | EORTC QLQ-HN43, quality of life |
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| | Minimal detectable difference |
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| | Minimal important change |
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| | Minimal important difference |
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| | Patient-reported outcomes |
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| | Subjective significance |
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| K10plus-PPN: | 1927947383 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ european organisation for research and treatment of cancer head and neck cancer module (EORTC QLQ-HN43) / Singer, Susanne [VerfasserIn]; November 2024 (Online-Ressource)
