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| Verfasst von: | Khaimov, Valeria [VerfasserIn]  |
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| | Grousl, Tomas [VerfasserIn] |
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| | Theer, Patrick [VerfasserIn] |
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| | Vainshtein, Yevhen [VerfasserIn] |
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| | Gläßer, Christine [VerfasserIn] |
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| | Mongis, Cyril [VerfasserIn] |
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| | Kramer, Günter [VerfasserIn] |
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| | Stoecklin, Georg [VerfasserIn] |
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| | Knop, Michael [VerfasserIn] |
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| | Mogk, Axel [VerfasserIn] |
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| | Bukau, Bernd [VerfasserIn] |
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| Titel: | Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress |
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| Verf.angabe: | Valeria Cherkasov, Tomas Grousl, Patrick Theer, Yevhen Vainshtein, Christine Glässer, Cyril Mongis, Günter Kramer, Georg Stoecklin, Michael Knop, Axel Mogk, Bernd Bukau |
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| E-Jahr: | 2015 |
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| Jahr: | 17 October 2015 |
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| Umfang: | 11 S. |
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| Teil: | volume:589 |
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| | year:2015 |
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| | number:23 |
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| | pages:3654-3664 |
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| | extent:11 |
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| Fussnoten: | Gesehen am 09.08.2017 |
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| Titel Quelle: | Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters |
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| Ort Quelle: | Chichester : Wiley, 1968 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 589(2015), 23, Seite 3654-3664 |
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| ISSN Quelle: | 1873-3468 |
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| Abstract: | Environmental stress causes the sequestration of proteins into insoluble deposits including cytoplasmic stress granules (SGs), containing mRNA and a variety of translation factors. Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co-localization screen and proteomic analysis of insoluble protein fractions. We identified novel SG components including essential aminoacyl-tRNA synthetases. Moreover, we discovered nucleus-associated deposits containing ribosome biogenesis factors. Our study suggests downregulation of cytosolic protein synthesis and nuclear ribosome production at multiple levels through heat shock induced protein sequestrations. |
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| DOI: | doi:10.1016/j.febslet.2015.10.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Kostenfrei: Volltext: http://dx.doi.org/10.1016/j.febslet.2015.10.010 |
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| | DOI: https://doi.org/10.1016/j.febslet.2015.10.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Chaperone |
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| | Cytoplasm |
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| | Heat shock |
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| | Heat-Shock Response |
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| | Organelle Biogenesis |
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| | Protein sequestration |
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| | Protein Transport |
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| | Proteomics |
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| | Ribosome biogenesis |
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| | Ribosomes |
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| | RNA, Messenger |
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| | Saccharomyces cerevisiae |
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| | Saccharomyces cerevisiae Proteins |
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| | Solubility |
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| | Stress granule |
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| | Translation |
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| K10plus-PPN: | 1562276638 |
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| Verknüpfungen: | → Zeitschrift |
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Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress / Khaimov, Valeria [VerfasserIn]; 17 October 2015 (Online-Ressource)
