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| Verfasst von: | Voloshanenko, Oksana [VerfasserIn]  |
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| | Rauscher, Benedikt [VerfasserIn] |
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| | Augustin, Iris [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells |
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| Verf.angabe: | Oksana Voloshanenko, Uwe Schwartz, Dominique Kranz, Benedikt Rauscher, Michael Linnebacher, Iris Augustin, Michael Boutros |
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| E-Jahr: | 2018 |
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| Jahr: | 16 February 2018 |
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| Fussnoten: | Gesehen am 29.03.2019 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 8(2018) Artikel-Nummer 3178, 14 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Wnt signaling is an evolutionarily conserved signaling route required for development and homeostasis. While canonical, β-catenin-dependent Wnt signaling is well studied and has been linked to many forms of cancer, much less is known about the role of non-canonical, β-catenin-independent Wnt signaling. Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. Independent experiments confirmed several target genes, including PLOD2, HADH, LCOR and REEP1 as non-canonical target genes in various colon cancer cells. Moreover, non-canonical Wnt target genes are regulated via RoR2, Dvl2, ATF2 and ATF4. Furthermore, we show that the ligands Wnt5a/b are upstream regulators of the non-canonical signature and moreover regulate proliferation of cancer cells in a β-catenin-independent manner. Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. |
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| DOI: | doi:10.1038/s41598-018-20641-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41598-018-20641-5 |
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| | Volltext: https://www.nature.com/articles/s41598-018-20641-5 |
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| | DOI: https://doi.org/10.1038/s41598-018-20641-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1662552874 |
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| Verknüpfungen: | → Zeitschrift |
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β-catenin-independent regulation of Wnt target genes by RoR2 and ATF2/ATF4 in colon cancer cells / Voloshanenko, Oksana [VerfasserIn]; 16 February 2018 (Online-Ressource)
