Circular RNAs in the cardiovascular system

• Verfasst von: Pedrosa da Costa Gomes, Clarissa [VerfasserIn]
• Verfasst von: Dieterich, Christoph [VerfasserIn]
• Titel: Circular RNAs in the cardiovascular system
• Verf.angabe: Clarissa P.C. Gomes, Antonio Salgado-Somoza, Esther E. Creemers, Christoph Dieterich, Mitja Lustrek, Yvan Devaux on behalf of the Cardiolinc network2
• E-Jahr: 2018
• Jahr: 25 February 2018
• Umfang: 11 S.
• Fussnoten: Gesehen am 10.05.2019
• Titel Quelle: Enthalten in: Non-coding RNA research
• Ort Quelle: Amsterdam : Elsevier, 2016
• Jahr Quelle: 2018
• Band/Heft Quelle: 3(2018), 1, Seite 1-11
• ISSN Quelle: 2468-0540
• DOI: doi:10.1016/j.ncrna.2018.02.002
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Artificial intelligence
• Sach-SW: Biomarker
• Sach-SW: Cardiovascular disease
• Sach-SW: Cardiovascular system
• Sach-SW: Circular RNAs
• Sach-SW: Non-coding RNAs
• K10plus-PPN: 1665159995

Abstract

Until recently considered as rare, circular RNAs (circRNAs) are emerging as important regulators of gene expression. They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs. Recent investigations showed that circRNAs are regulated in the cardiovascular system and participate in its physiological and pathological development. In this review article, we will provide an overview of the role of circRNAs in cardiovascular health and disease. After a description of the biogenesis of circRNAs, we will summarize what is known of the expression, regulation and function of circRNAs in the cardiovascular system. We will then address some technical aspects of circRNAs research, discussing how artificial intelligence may aid in circRNAs research. Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed.