| |  Online-Ressource |
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| Verfasst von: | Groeneweg, Femke [VerfasserIn]  |
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| | Trattnig, Christa [VerfasserIn] |
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| | Kuhse, Jochen [VerfasserIn] |
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| | Nawrotzki, Ralph [VerfasserIn] |
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| | Kirsch, Joachim [VerfasserIn] |
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| Titel: | Gephyrin |
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| Titelzusatz: | a key regulatory protein of inhibitory synapses and beyond |
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| Verf.angabe: | Femke L. Groeneweg, Christa Trattnig, Jochen Kuhse, Ralph A. Nawrotzki, Joachim Kirsch |
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| E-Jahr: | 2018 |
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| Jahr: | 27 September 2018 |
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| Umfang: | 20 S. |
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| Fussnoten: | Gesehen am 17.05.2019 |
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| Titel Quelle: | Enthalten in: Histochemistry and cell biology |
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| Ort Quelle: | Berlin : Springer, 1958 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 150(2018), 5, Seite 489-508 |
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| ISSN Quelle: | 1432-119X |
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| Abstract: | Scaffolding proteins underlying postsynaptic membrane specializations are important structural and functional components of both excitatory and inhibitory synapses. At inhibitory synapses, gephyrin was identified as anchoring protein. Gephyrin self-assembles into a complex flat submembranous lattice that slows the lateral mobility of glycine and GABAA receptors, thus allowing for their clustering at postsynaptic sites. The structure and stability of the gephyrin lattice is dynamically regulated by posttranslational modifications and interactions with binding partners. As gephyrin is the core scaffolding protein for virtually all inhibitory synapses, any changes in the structure or stability of its lattice can profoundly change the packing density of inhibitory receptors and, therefore, alter inhibitory drive. Intriguingly, gephyrin plays a completely independent role in non-neuronal cells, where it facilitates two steps in the biosynthesis of the molybdenum cofactor. In this review, we provide an overview of the role of gephyrin at inhibitory synapses and beyond. We discuss its dynamic regulation, the nanoscale architecture of its synaptic lattice, and the implications of gephyrin dysfunction for neuropathologic conditions, such as Alzheimer’s disease and epilepsy. |
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| DOI: | doi:10.1007/s00418-018-1725-2 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1007/s00418-018-1725-2 |
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| | Volltext: https://doi.org/10.1007/s00418-018-1725-2 |
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| | DOI: https://doi.org/10.1007/s00418-018-1725-2 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Alzheimer |
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| | Collybistin |
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| | Epilepsy |
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| | GABA |
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| | Gephyrin |
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| | Glycine |
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| K10plus-PPN: | 1665874538 |
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| Verknüpfungen: | → Zeitschrift |
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