Vitamin D and cardiovascular disease prevention

• Verfasst von: Pilz, Stefan [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Vitamin D and cardiovascular disease prevention
• Verf.angabe: Stefan Pilz, Nicolas Verheyen, Martin R. Grübler, Andreas Tomaschitz and Winfried März
• E-Jahr: 2016
• Jahr: 06 May 2016
• Umfang: 14 S.
• Fussnoten: Gesehen am 09.07.2019
• Titel Quelle: Enthalten in: Nature reviews. Cardiology
• Ort Quelle: Basingstoke : Nature Publishing Group, 2009
• Jahr Quelle: 2016
• Band/Heft Quelle: 13(2016), 7, Seite 404-417
• ISSN Quelle: 1759-5010
• DOI: doi:10.1038/nrcardio.2016.73
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1668813378

Abstract

Vitamin D is a precursor of the steroid hormone calcitriol that is crucial for bone and mineral metabolism. Both the high prevalence of vitamin D deficiency in the general population and the identification of the vitamin D receptor in the heart and blood vessels raised interest in the potential cardiovascular effects of vitamin D. Experimental studies have demonstrated various cardiovascular protective actions of vitamin D, but vitamin D intoxication in animals is known to induce vascular calcification. In meta-analyses of epidemiological studies, vitamin D deficiency is associated with an increased cardiovascular risk. Findings from Mendelian randomization studies and randomized, controlled trials (RCTs) do not indicate significant effects of a general vitamin D supplementation on cardiovascular outcomes. Previous RCTs, however, were not adequately designed to address extraskeletal events, and did not focus on vitamin D-deficient individuals. Therefore, currently available evidence does not support cardiovascular benefits or harms of vitamin D supplementation with the commonly used doses, and whether vitamin D has cardiovascular effects in individuals with overt vitamin D deficiency remains to be evaluated. Here, we provide an update on clinical studies on vitamin D and cardiovascular risk, discuss ongoing vitamin D research, and consider the management of vitamin D deficiency from a cardiovascular health perspective.