Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Kumru, Gizem [VerfasserIn]  |
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| | Unterrainer, Christian [VerfasserIn] |
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| | Süsal, Caner [VerfasserIn] |
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| Titel: | Critical evaluation of a possible role of HLA epitope matching in kidney transplantation |
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| Verf.angabe: | Gizem Kumru Sahin, Christian Unterrainer, Caner Süsal |
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| E-Jahr: | 2020 |
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| Jahr: | 17 January 2020 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 02.04.2020 |
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| Titel Quelle: | Enthalten in: Transplantation reviews |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1987 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 34(2020), 2, Seite 100533 |
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| ISSN Quelle: | 1557-9816 |
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| Abstract: | Human leukocyte antigen (HLA) matching is one of the cornerstones of organ allocation in deceased-donor kidney transplantation. Increased numbers of HLA allele mismatches are associated with a higher risk of immunological rejection, de novo donor-specific HLA antibody development and graft failure. HLA epitopes are defined as the specific portions of HLA molecules to which antibodies and T-cell receptors bind with their paratopes. The same epitope can be present on different HLA alleles. Therefore, HLA matching at the epitope instead of allele level theoretically offers a more precise assessment of donor-recipient HLA compatibility and may more effectively prevent sensitization against foreign tissue. In this review, we describe the different options proposed to define clinically relevant HLA epitopes and critically discuss the potential role of HLA epitope matching in kidney transplantation. |
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| DOI: | doi:10.1016/j.trre.2020.100533 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.trre.2020.100533 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0955470X20300069 |
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| | DOI: https://doi.org/10.1016/j.trre.2020.100533 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Donor-specific antibody |
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| | Epitope |
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| | Histocompatibility |
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| | Human leukocyte antigen |
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| | Kidney transplantation |
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| | Matching |
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| K10plus-PPN: | 1693806355 |
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| Verknüpfungen: | → Zeitschrift |
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Critical evaluation of a possible role of HLA epitope matching in kidney transplantation / Kumru, Gizem [VerfasserIn]; 17 January 2020 (Online-Ressource)
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