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| Verfasst von: | Middeke, Jan Moritz [VerfasserIn]  |
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| | Herold, Sylvia [VerfasserIn] |
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| | Rücker‐Braun, Elke [VerfasserIn] |
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| | Berdel, Wolfgang E. [VerfasserIn] |
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| | Stelljes, Matthias [VerfasserIn] |
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| | Kaufmann, Martin [VerfasserIn] |
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| | Schäfer‐Eckart, Kerstin [VerfasserIn] |
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| | Baldus, Claudia D. [VerfasserIn] |
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| | Stuhlmann, Reingard [VerfasserIn] |
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| | Einsele, Hermann [VerfasserIn] |
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| | Rösler, Wolf [VerfasserIn] |
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| | Serve, Hubert [VerfasserIn] |
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| | Hänel, Mathias [VerfasserIn] |
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| | Sohlbach, Kristina [VerfasserIn] |
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| | Klesse, Christian [VerfasserIn] |
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| | Mohr, Brigitte [VerfasserIn] |
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| | Heidenreich, Falk [VerfasserIn] |
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| | Stölzel, Friedrich [VerfasserIn] |
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| | Röllig, Christoph [VerfasserIn] |
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| | Platzbecker, Uwe [VerfasserIn] |
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| | Ehninger, Gerhard [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Thiede, Christian [VerfasserIn] |
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| | Schetelig, Johannes [VerfasserIn] |
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| Titel: | TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation |
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| Mitwirkende: | Ho, Anthony Dick |
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| Verf.angabe: | Jan M. Middeke, Sylvia Herold, Elke Rücker‐Braun, Wolfgang E. Berdel, Matthias Stelljes, Martin Kaufmann, Kerstin Schäfer‐Eckart, Claudia D. Baldus, Reingard Stuhlmann, Anthony D. Ho, Hermann Einsele, Wolf Rösler, Hubert Serve, Mathias Hänel, Kristina Sohlbach, Christian Klesse, Brigitte Mohr, Falk Heidenreich, Friedrich Stölzel, Christoph Röllig, Uwe Platzbecker, Gerhard Ehninger, Martin Bornhäuser, Christian Thiede, Johannes Schetelig and for the Study Alliance Leukaemia (SAL) |
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| E-Jahr: | 2016 |
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| Jahr: | 13 January 2016 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 30.04.2020 |
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| Titel Quelle: | Enthalten in: British journal of haematology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1955 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 172(2016), 6, Seite 914-922 |
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| ISSN Quelle: | 1365-2141 |
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| Abstract: | Treatment success in patients with acute myeloid leukaemia (AML) is heterogeneous. Cytogenetic and molecular alterations are strong prognostic factors, which have been used to individualize treatment. Here, we studied the impact of TP53 mutations on the outcome of AML patients with adverse cytogenetic risk treated with allogeneic haematopoietic stem cell transplantation (HSCT). Samples of 97 patients with AML and adverse-risk cytogenetics who had received a HSCT within three randomized trials were analysed. Complete sequencing of the TP53 coding region was performed using next generation sequencing. The median age was 51 years. Overall, TP53 mutations were found in 40 patients (41%). With a median follow up of 67 months, the three-year probabilities of overall survival (OS) and event-free survival for patients with TP53 wild type were 33% [95% confidence interval (CI), 21% to 45%] and 24% (95% CI, 13% to 35%) compared to 10% (95% CI, 0% to 19%) and 8% (95% CI, 0% to 16%) (P = 0·002 and P = 0·007) for those with mutated TP53, respectively. In multivariate analysis, the TP53-mutation status had a negative impact on OS (Hazard Ratio = 1·7; P = 0·066). Mutational analysis of TP53 might be an important additional tool to predict outcome after HSCT in patients with adverse karyotype AML. |
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| DOI: | doi:10.1111/bjh.13912 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/bjh.13912 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bjh.13912 |
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| | DOI: https://doi.org/10.1111/bjh.13912 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | acute myeloid leukaemia |
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| | allogeneic transplantation |
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| | TP53 mutation |
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| K10plus-PPN: | 1696940125 |
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| Verknüpfungen: | → Zeitschrift |
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TP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation / Middeke, Jan Moritz [VerfasserIn]; 13 January 2016 (Online-Ressource)
