LIM homeobox protein 5 (Lhx5) is essential for mamillary body development

• Verfasst von: Miquelajauregui Graf, Amaya [VerfasserIn]
• Verfasst von: Heide, Michael [VerfasserIn]
• Verfasst von: Alvarez-Bolado, Gonzalo [VerfasserIn]
• Titel: LIM homeobox protein 5 (Lhx5) is essential for mamillary body development
• Verf.angabe: Amaya Miquelajáuregui, Teresa Sandoval-Schaefer, Miriam Martínez-Armenta, Leonor Pérez-Martínez, Alfonso Cárabez, Yangu Zhao, Michael Heide, Gonzalo Alvarez-Bolado and Alfredo Varela-Echavarría
• E-Jahr: 2015
• Jahr: 27 October 2015
• Umfang: 10 S.
• Fussnoten: Gesehen am 08.06.2020
• Titel Quelle: Enthalten in: Frontiers in neuroanatomy
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2015
• Band/Heft Quelle: 9(2015) Artikel-Nummer 136, 10 Seiten
• ISSN Quelle: 1662-5129
• DOI: doi:10.3389/fnana.2015.00136
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1700136135

Abstract

The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts. The MM markers Foxb1, Sim2 and Lhx1 are absent in Lhx5 knock-out mice from early embryonic stages, suggesting abnormal specification of this region. This was supported by the absence of Nkx2.1 and expansion of Shh in the prospective mamillary area. Interestingly, we also found an ectopic domain expressing Lhx2 and Lhx9 along the anterio-posterior hypothalamic axis. Our results suggest that Lhx5 controls early aspects of hypothalamic development by regulating gene expression and cellular specification in the prospective MM.