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Verfasst von:Schultheiß, Maximilian [VerfasserIn]   i
 Schommer, Kai [VerfasserIn]   i
 Schatz, Andreas [VerfasserIn]   i
 Wilhelm, Barbara [VerfasserIn]   i
 Peters, Tobias Markus [VerfasserIn]   i
 Fischer, Manuel Dominik [VerfasserIn]   i
 Zrenner, Eberhart [VerfasserIn]   i
 Bartz-Schmidt, Karl U. [VerfasserIn]   i
 Gekeler, Florian Eberhard [VerfasserIn]   i
 Willmann, Gabriel [VerfasserIn]   i
Titel:Pupillary light reaction during high altitude exposure
Verf.angabe:Maximilian Schultheiss, Kai Schommer, Andreas Schatz, Barbara Wilhelm, Tobias Peters, M. Dominik Fischer, Eberhart Zrenner, Karl U. Bartz-Schmidt, Florian Gekeler, Gabriel Willmann
E-Jahr:2014
Jahr:February 4, 2014
Umfang:6 S.
Fussnoten:Gesehen am 06.10.2020
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2014
Band/Heft Quelle:9(2014,2) Artikel-Nummer e87889, 6 Seiten
ISSN Quelle:1932-6203
Abstract:Purpose This study aimed to quantify the pupillary light reaction during high altitude exposure using the state of the art Compact Integrated Pupillograph (CIP) and to investigate a potential correlation of altered pupil reaction with severity of acute mountain sickness (AMS). This work is related to the Tübingen High Altitude Ophthalmology (THAO) study. Methods Parameters of pupil dynamics (initial diameter, amplitude, relative amplitude, latency, constriction velocity) were quantified in 14 healthy volunteers at baseline (341 m) and high altitude (4559 m) over several days using the CIP. Scores of AMS, peripheral oxygen saturation and heart rate were assessed for respective correlations with pupil dynamics. For statistical analysis JMP was used and data are shown in terms of intra-individual normalized values (value during exposure/value at baseline) and the 95% confidence interval for each time point. Results During high altitude exposure the initial diameter size was significantly reduced (p<0.05). In contrast, the amplitude, the relative amplitude and the contraction velocity of the light reaction were significantly increased (p<0.05) on all days measured at high altitude. The latency did not show any significant differences at high altitude compared to baseline recordings. Changes in pupil parameters did not correlate with scores of AMS. Conclusions Key parameters of the pupillary light reaction are significantly altered at high altitude. We hypothesize that high altitude hypoxia itself as well as known side effects of high altitude exposure such as fatigue or exhaustion after ascent may account for an altered pupillogram. Interestingly, none of these changes are related to AMS.
DOI:doi:10.1371/journal.pone.0087889
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0087889
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087889
 DOI: https://doi.org/10.1371/journal.pone.0087889
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Altitude sickness
 Central nervous system
 Edema
 Fatigue
 Headaches
 Heart rate
 Hypoxia
 Oxygen
K10plus-PPN:1734801298
Verknüpfungen:→ Zeitschrift

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