A framework for modelling gene regulation which accommodates non-equilibrium mechanisms

• Verfasst von: Ahsendorf, Tobias [VerfasserIn]
• Verfasst von: Eils, Roland [VerfasserIn]
• Titel: A framework for modelling gene regulation which accommodates non-equilibrium mechanisms
• Verf.angabe: Tobias Ahsendorf, Felix Wong, Roland Eils and Jeremy Gunawardena
• E-Jahr: 2014
• Jahr: 05 December 2014
• Umfang: 23 S.
• Fussnoten: Gesehen am 09.10.2020
• Titel Quelle: Enthalten in: BMC biology
• Ort Quelle: Berlin : Springer, 2003
• Jahr Quelle: 2014
• Band/Heft Quelle: 12(2014) Artikel-Nummer 102, 23 Seiten
• ISSN Quelle: 1741-7007
• DOI: doi:10.1186/s12915-014-0102-4
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1735253480

Abstract

Gene regulation has, for the most part, been quantitatively analysed by assuming that regulatory mechanisms operate at thermodynamic equilibrium. This formalism was originally developed to analyse the binding and unbinding of transcription factors from naked DNA in eubacteria. Although widely used, it has made it difficult to understand the role of energy-dissipating, epigenetic mechanisms, such as DNA methylation, nucleosome remodelling and post-translational modification of histones and co-regulators, which act together with transcription factors to regulate gene expression in eukaryotes.