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Status: Bibliographieeintrag

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Verfasst von:Dahle, Tordis J. [VerfasserIn]   i
 Rusten, Espen [VerfasserIn]   i
 Stokkevåg, Camilla Hanquist [VerfasserIn]   i
 Silvoniemi, Antti [VerfasserIn]   i
 Mairani, Andrea [VerfasserIn]   i
 Fjæra, Lars Fredrik [VerfasserIn]   i
 Rørvik, Eivind [VerfasserIn]   i
 Henjum, Helge [VerfasserIn]   i
 Wright, Pauliina [VerfasserIn]   i
 Boer, Camilla Grindeland [VerfasserIn]   i
 Forsback, Sarita [VerfasserIn]   i
 Minn, Heikki [VerfasserIn]   i
 Malinen, Eirik [VerfasserIn]   i
 Ytre-Hauge, Kristian Smeland [VerfasserIn]   i
Titel:The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors
Verf.angabe:Tordis Johnsen Dahle, Espen Rusten, Camilla Hanquist Stokkevåg, Antti Silvoniemi, Andrea Mairani, Lars Fredrik Fjæra, Eivind Rørvik, Helge Henjum, Pauliina Wright, Camilla Grindeland Boer, Sarita Forsback, Heikki Minn, Eirik Malinen, Kristian Smeland Ytre-Hauge
E-Jahr:2020
Jahr:16 July 2020
Umfang:7 S.
Fussnoten:Gesehen am 18.12.2020
Titel Quelle:Enthalten in: Physica medica
Ort Quelle:Amsterdam : Elsevier, 1996
Jahr Quelle:2020
Band/Heft Quelle:76(2020), Seite 166-172
ISSN Quelle:1724-191X
Abstract:Introduction - The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of both OER and relative biological effectiveness (RBE) in biologically weighted dose (ROWD) calculations in proton therapy and applied this to explore the impact of hypoxia. - Methods - The RBE-weighted dose was adapted for hypoxia by making RBE model parameters dependent on the OER, in addition to the linear energy transfer (LET). The OER depends on the partial oxygen pressure (pO2) and LET. To demonstrate model performance, calculations were done with spread-out Bragg peaks (SOBP) in water phantoms with pO2 ranging from strongly hypoxic to normoxic (0.01-30 mmHg) and with a head and neck cancer proton plan optimized with an RBE of 1.1 and pO2 estimated voxel-by-voxel using [18F]-EF5 PET. An RBE of 1.1 and the Rørvik RBE model were used for the ROWD calculations. - Results - The SOBP in water had decreasing ROWD with decreasing pO2. In the plans accounting for oxygenation, the median target doses were approximately a factor 1.1 lower than the corresponding plans which did not consider the OER. Hypoxia adapted target ROWDs were considerably more heterogeneous than the RBE1.1-weighted doses. - Conclusion - We realized a Monte Carlo based tool for calculating the ROWD. Read-in of patient pO2 and estimation of ROWD with flexibility in choice of RBE model was achieved, giving a tool that may be useful in future clinical applications of hypoxia-guided particle therapy.
DOI:doi:10.1016/j.ejmp.2020.07.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ejmp.2020.07.003
 Volltext: http://www.sciencedirect.com/science/article/pii/S1120179720301630
 DOI: https://doi.org/10.1016/j.ejmp.2020.07.003
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Hypoxia
 Oxygen enhancement ratio
 Proton therapy
 Relative biological effectiveness
K10plus-PPN:1743276478
Verknüpfungen:→ Zeitschrift

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