A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs

• Verfasst von: Eichhorst, Sören [VerfasserIn]
• Verfasst von: Li-Weber, Min [VerfasserIn]
• Verfasst von: Schulze-Bergkamen, Henning [VerfasserIn]
• Verfasst von: Angel, Peter [VerfasserIn]
• Verfasst von: Krammer, Peter H. [VerfasserIn]
• Titel: A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs
• Verf.angabe: Sören T. Eichhorst, Martina Müller, Min Li-Weber, Henning Schulze-Bergkamen, Peter Angel, and Peter H. Krammer
• E-Jahr: 2000
• Jahr: Oct. 2000
• Umfang: 12 S.
• Teil: volume:20
• Teil: year:2000
• Teil: number:20
• Teil: pages:7826-7837
• Teil: extent:12
• Fussnoten: Gesehen am 26.04.2021
• Titel Quelle: Enthalten in: Molecular and cellular biology
• Ort Quelle: Washington, DC : Soc., 1981
• Jahr Quelle: 2000
• Band/Heft Quelle: 20(2000), 20, Seite 7826-7837
• ISSN Quelle: 1098-5549
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1755914237

Abstract

The CD95 (also called APO-1 or Fas) system plays a major role in the induction of apoptosis in lymphoid and nonlymphoid tissues in response to a variety of extracellular signals, including chemotherapeutic drugs. Here we report that the CD95 ligand (CD95L) is upregulated in hepatoma cells upon treatment with antineoplastic drugs. Upregulation by different chemotherapeutic drugs is functionally relevant for drug-induced apoptosis and is mediated by transcriptional mechanisms. The MEKK1/JNKK pathway and a novel AP-1 element in the CD95L promoter downstream of the TATA box are required for CD95L upregulation. Thus, understanding the mechanisms of CD95-mediated apoptosis through CD95L upregulation upon treatment of hepatocellular carcinomas with chemotherapeutic drugs may contribute to the improvement of anticancer chemotherapy.