Specialized regulatory T cells control venous blood clot resolution through SPARC

• Verfasst von: Shahneh, Fatemeh Zare [VerfasserIn]
• Verfasst von: Grill, Alexandra [VerfasserIn]
• Verfasst von: Klein, Matthias [VerfasserIn]
• Verfasst von: Frauhammer, Felix [VerfasserIn]
• Verfasst von: Bopp, Tobias [VerfasserIn]
• Verfasst von: Schäfer, Katrin [VerfasserIn]
• Verfasst von: Raker, Verena [VerfasserIn]
• Verfasst von: Becker, Christian [VerfasserIn]
• Titel: Specialized regulatory T cells control venous blood clot resolution through SPARC
• Verf.angabe: Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schäfer, Verena K. Raker, Christian Becker
• E-Jahr: 2021
• Jahr: March 18, 2021
• Umfang: 10 S.
• Fussnoten: Gesehen am 07.06.2021
• Titel Quelle: Enthalten in: Blood
• Ort Quelle: Washington, DC : American Society of Hematology, 1946
• Jahr Quelle: 2021
• Band/Heft Quelle: 137(2021), 11, Seite 1517-1526
• ISSN Quelle: 1528-0020
• DOI: doi:10.1182/blood.2020005407
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1759902683

Abstract

The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption.