| |  Online-Ressource |
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| Verfasst von: | Hegger, Patricia [VerfasserIn]  |
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| | Kupka, Julia Stefanie [VerfasserIn] |
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| | Minsky, Burcu Baykal [VerfasserIn] |
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| | Schädel, Nicole [VerfasserIn] |
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| | Petri, Nadja [VerfasserIn] |
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| | Laschat, Sabine [VerfasserIn] |
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| | Böhm, Heike [VerfasserIn] |
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| Titel: | Charge matters |
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| Titelzusatz: | modulating secondary interactions in hyaluronan hydrogels |
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| Verf.angabe: | Patricia S. Hegger, Julia Kupka, Burcu Baykal Minsky, Nicole Schädel, Nadja Petri, Sabine Laschat, and Heike Boehm |
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| E-Jahr: | 2017 |
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| Jahr: | 05 September 2017 |
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| Umfang: | 5 S. |
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| Teil: | volume:2 |
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| | year:2017 |
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| | number:25 |
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| | pages:7701-7705 |
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| | extent:5 |
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| Fussnoten: | Gesehen am 17.08.2021 |
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| Titel Quelle: | Enthalten in: ChemistrySelect |
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| Ort Quelle: | Weinheim : Wiley-VCH, 2016 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 2(2017), 25, Seite 7701-7705 |
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| ISSN Quelle: | 2365-6549 |
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| Abstract: | Hyaluronic acid (HA) is a vital, functional component of the extracellular matrix (ECM). Following a synthetic biology approach, we designed polyelectrolyte hydrogels composed of HA as a polymeric backbone interconnected by short covalent crosslinkers. Utilizing a thiol-Michael addition, defined network structures are created, which can be modulated by the aromatic core and charge of the crosslinkers. With increasing negative network charge, varied both through the charge of the crosslinker and the degree of functionalization of the HA chain, the Young's modulus of the hydrogels decreases linearly as swelling ratios increase. Interestingly, secondary interactions with aromatic crosslinkers are stronger for elastin inspired crosslinkers with a pyridinium core compared to analogous triazolium crosslinkers. Based on the defined covalent interconnectivity of these HA-hydrogels, we were able to demonstrate the specific electrostatic and aromatic interactions induced by different short crosslinkers. |
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| DOI: | doi:10.1002/slct.201701908 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/slct.201701908 |
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| | Volltext: https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.201701908 |
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| | DOI: https://doi.org/10.1002/slct.201701908 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | carbohydrates |
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| | electrostatic interaction |
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| | hyaluronan |
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| | polyelectrolyte hydrogel |
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| | synthetic biology |
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| K10plus-PPN: | 1767189443 |
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| Verknüpfungen: | → Zeitschrift |
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Charge matters / Hegger, Patricia [VerfasserIn]; 05 September 2017 (Online-Ressource)
