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| Verfasst von: | Filbeck, Sebastian [VerfasserIn]  |
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| | Cerullo, Federico [VerfasserIn] |
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| | Pfeffer, Stefan [VerfasserIn] |
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| | Joazeiro, Claudio A. P. [VerfasserIn] |
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| Titel: | Ribosome-associated quality-control mechanisms from bacteria to humans |
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| Verf.angabe: | Sebastian Filbeck, Federico Cerullo, Stefan Pfeffer, and Claudio A.P. Joazeiro |
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| E-Jahr: | 2022 |
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| Jahr: | 21 April 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 01.07.2022 |
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| Titel Quelle: | Enthalten in: Molecular cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1997 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 82(2022), 8, Seite 1451-1466 |
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| ISSN Quelle: | 1097-4164 |
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| Abstract: | Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides produced by interrupted translation. Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, which sense large ribosomal subunits obstructed with nascent chains and then promote nascent-chain proteolysis. In canonical eukaryotic RQC, NEMF stabilizes the LTN1/Listerin E3 ligase binding to obstructed ribosomal subunits for nascent-chain ubiquitylation. Furthermore, NEMF orthologs across evolution modify nascent chains by mediating C-terminal, untemplated polypeptide elongation. In eukaryotes, this process exposes ribosome-buried nascent-chain lysines, the ubiquitin acceptor sites, to LTN1. Remarkably, in both bacteria and eukaryotes, C-terminal tails also have an extra-ribosomal function as degrons. Here, we discuss recent findings on RQC mechanisms and briefly review how ribosomal stalling is sensed upstream of RQC, including via ribosome collisions, from an evolutionary perspective. Because RQC defects impair cellular fitness and cause neurodegeneration, this knowledge provides a framework for pathway-related biology and disease studies. |
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| DOI: | doi:10.1016/j.molcel.2022.03.038 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.molcel.2022.03.038 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1097276522002945 |
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| | DOI: https://doi.org/10.1016/j.molcel.2022.03.038 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alanine tail |
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| | C-terminal tail |
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| | CAT tail |
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| | KLHDC10 |
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| | Listerin |
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| | LTN1 |
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| | NEMF |
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| | Pirh2 |
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| | quality control |
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| | ribosome |
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| | ribosome collision |
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| | ribosome stalling |
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| | RQC |
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| | Rqc2 |
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| | RqcH |
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| | translation |
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| K10plus-PPN: | 1808795032 |
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| Verknüpfungen: | → Zeitschrift |
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Ribosome-associated quality-control mechanisms from bacteria to humans / Filbeck, Sebastian [VerfasserIn]; 21 April 2022 (Online-Ressource)
