| |  Online-Ressource |
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| Verfasst von: | Lajqi, Trim [VerfasserIn]  |
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| | Frommhold, David [VerfasserIn] |
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| | Braun, Maylis [VerfasserIn] |
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| | Kranig, Simon A. [VerfasserIn] |
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| | Pöschl, Johannes [VerfasserIn] |
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| | Hudalla, Hannes [VerfasserIn] |
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| Titel: | Gram-positive Staphylococcus aureus LTA promotes distinct memory-like effects in murine bone marrow neutrophils |
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| Verf.angabe: | Trim Lajqi, David Frommhold, Maylis Braun, Simon Alexander Kranig, Johannes Pöschl, Hannes Hudalla |
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| E-Jahr: | 2022 |
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| Jahr: | 7 May 2022 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 13.07.2022 |
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| Titel Quelle: | Enthalten in: Cellular immunology |
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| Ort Quelle: | Orlando, Fla. : Academic Press, 1970 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 376(2022), Artikel-ID 104535, Seite 1-9 |
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| ISSN Quelle: | 1090-2163 |
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| Abstract: | Neutrophils primarily act as first responders in acute infection and directly maintain inflammatory responses. However, a growing body of evidence suggests that neutrophils also bear the potential to mediate chronic inflammation by exhibiting memory-like features. We now asked whether bone marrow-derived murine neutrophils can be primed by lipoteichoic acid (LTA) from gram-positive S. aureus. We found that low-dose (1ng/mL) LTA-priming promoted increased production of pro-inflammatory mediators (TNF-α, IL-6, ROS), whereas high-dose (10µg/mL) priming resulted in opposing reactions marked by increased IL-10 and suppressed pro-inflammatory mediators upon a second stimulus. A similar pattern of pro-inflammatory activation (trained sensitivity) and anti-inflammatory properties (tolerance) was recapitulated in cellular functional in vitro assays (transmigration and phagocytosis). Priming by LTA correlated with TLR2/MyD88-mediated regulation of NFκB-p65 through intermediate PI3Ks/MAPK. Collectively, our data suggest a previously unknown capacity of neutrophils to be differentially primed by varying doses of LTA, endorsing memory-like features in neutrophils. |
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| DOI: | doi:10.1016/j.cellimm.2022.104535 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cellimm.2022.104535 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0008874922000594 |
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| | DOI: https://doi.org/10.1016/j.cellimm.2022.104535 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1810098564 |
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| Verknüpfungen: | → Zeitschrift |
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Gram-positive Staphylococcus aureus LTA promotes distinct memory-like effects in murine bone marrow neutrophils / Lajqi, Trim [VerfasserIn]; 7 May 2022 (Online-Ressource)
