| |  Online-Ressource |
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| Verfasst von: | Schaich, Markus [VerfasserIn]  |
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| | Röllig, Christoph [VerfasserIn] |
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| | Soucek, Silke [VerfasserIn] |
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| | Kramer, Michael [VerfasserIn] |
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| | Thiede, Christian [VerfasserIn] |
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| | Mohr, Brigitte [VerfasserIn] |
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| | Oelschlaegel, Uta [VerfasserIn] |
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| | Schmitz, Norbert [VerfasserIn] |
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| | Stuhlmann, Reingard [VerfasserIn] |
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| | Wandt, Hannes [VerfasserIn] |
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| | Schäfer-Eckart, Kerstin [VerfasserIn] |
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| | Aulitzky, Walter [VerfasserIn] |
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| | Kaufmann, Martin [VerfasserIn] |
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| | Bodenstein, Heinrich [VerfasserIn] |
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| | Tischler, Joachim [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Krämer, Alwin [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Schetelig, Johannes [VerfasserIn] |
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| | Ehninger, Gerhard [VerfasserIn] |
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| Titel: | Cytarabine dose of 36 g/m2 compared with 12 g/m2 within first consolidation in acute myeloid leukemia |
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| Titelzusatz: | results of patients enrolled onto the prospective randomized AML96 study |
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| Verf.angabe: | Markus Schaich, Christoph Röllig, Silke Soucek, Michael Kramer, Christian Thiede, Brigitte Mohr, Uta Oelschlaegel, Norbert Schmitz, Reingard Stuhlmann, Hannes Wandt, Kerstin Schäfer-Eckart, Walter Aulitzky, Martin Kaufmann, Heinrich Bodenstein, Joachim Tischler, Anthony Ho, Alwin Krämer, Martin Bornhäuser, Johannes Schetelig, and Gerhard Ehninger |
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| E-Jahr: | 2011 |
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| Jahr: | May 23, 2011 |
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| Umfang: | 7 S. |
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| Fussnoten: | Im Titel ist die Zahl 2 jeweils hochgestellt ; Gesehen am 07.10.2022 |
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| Titel Quelle: | Enthalten in: Journal of clinical oncology |
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| Ort Quelle: | Alexandria, Va. : American Society of Clinical Oncology, 1983 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 29(2011), 19, Seite 2696-2702 |
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| ISSN Quelle: | 1527-7755 |
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| Abstract: | Purpose - - To assess the optimal cumulative dose of cytarabine for treatment of young adults with acute myeloid leukemia (AML) within a prospective multicenter treatment trial. - - Patients and Methods - - Between 1996 and 2003, 933 patients (median age, 47 years; range 15 to 60 years) with untreated AML were randomly assigned at diagnosis to receive cytarabine within the first consolidation therapy at either a intermediate-dose of 12 g/m2 (I-MAC) or a high-dose of 36 g/m2 (H-MAC) combined with mitoxantrone. Autologous hematopoietic stem-cell transplantation or intermediate-dose cytarabine (10 g/m2) were offered as second consolidation. Patients with a matched donor could receive an allogeneic transplantation in a risk-adapted manner. - - Results - - After double induction therapy including intermediate-dose cytarabine (10 g/m2), mitoxantrone, etoposide, and amsacrine, complete remission was achieved in 66% of patients. In the primary efficacy analysis population, a consolidation with either I-MAC or H-MAC did not result in significant differences in the 5-year overall (30% v 33%; P = .77) or disease-free survival (37% v 38%; P = .86) according to the intention-to-treat analysis. Besides a prolongation of neutropenia and higher transfusion demands in the H-MAC arm, rates of serious adverse events were comparable in the two groups. - - Conclusion - - In young adults with AML receiving intermediate-dose cytarabine induction, intensification of the cytarabine dose beyond 12 g/m2 within first consolidation did not improve treatment outcome. |
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| DOI: | doi:10.1200/JCO.2010.33.7303 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1200/JCO.2010.33.7303 |
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| | Volltext: https://ascopubs.org/doi/10.1200/JCO.2010.33.7303 |
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| | DOI: https://doi.org/10.1200/JCO.2010.33.7303 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1818221233 |
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| Verknüpfungen: | → Zeitschrift |
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Cytarabine dose of 36 g/m2 compared with 12 g/m2 within first consolidation in acute myeloid leukemia / Schaich, Markus [VerfasserIn]; May 23, 2011 (Online-Ressource)
