HLA-DRB1[asterisk]0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone

• Verfasst von: Mackensen, Friederike [VerfasserIn]
• Verfasst von: David, Felix [VerfasserIn]
• Verfasst von: Schwenger, Vedat [VerfasserIn]
• Verfasst von: Smith, L. K. [VerfasserIn]
• Verfasst von: Rajalingam, R. [VerfasserIn]
• Verfasst von: Levinson, R. D. [VerfasserIn]
• Verfasst von: Austin, C. R. [VerfasserIn]
• Verfasst von: Houghton, D. [VerfasserIn]
• Verfasst von: Martin, T. M. [VerfasserIn]
• Verfasst von: Rosenbaum, J. T. [VerfasserIn]
• Titel: HLA-DRB1[asterisk]0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone
• Verf.angabe: F. Mackensen, F. David, V. Schwenger, L.K. Smith, R. Rajalingam, R.D. Levinson, C.R. Austin, D. Houghton, T.M. Martin, J.T. Rosenbaum
• Jahr: 2011
• Umfang: 5 S.
• Fussnoten: Published online first 7 November 2010 ; Im Titel wird [asterisk] als Sternchen dargestellt ; Gesehen am 24.11.2022
• Titel Quelle: Enthalten in: British journal of ophthalmology
• Ort Quelle: London : BMJ Publ. Group, 1917
• Jahr Quelle: 2011
• Band/Heft Quelle: 95(2011), 7, Seite 971-975
• ISSN Quelle: 1468-2079
• DOI: doi:10.1136/bjo.2010.187955
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: diagnostic tests/investigation
• Sach-SW: genetics
• Sach-SW: HLA
• Sach-SW: inflammation
• Sach-SW: interstitial nephritis
• Sach-SW: Iris
• Sach-SW: TINU
• Sach-SW: Uveitis
• K10plus-PPN: 1823546153

Abstract

Background Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare form of uveitis. Previously, the authors had demonstrated a strong association of human leukocyte antigen (HLA) DRB1*0102 with TINU. Here, the authors performed HLA analysis on subjects with isolated bilateral sudden-onset uveitis (as in the TINU subtype) or with isolated tubulointerstitial nephritis (TIN). - Methods Patients with sudden onset, anterior, bilateral uveitis not fulfilling a diagnosis of TINU were identified. Pathology reports were reviewed to identify subjects with biopsy-proven TIN. Molecular typing of the HLA-DRB1 gene was performed by the Luminex technology-based sequence-specific oligonucleotide (SSO) hybridisation method (One Lambda, Canoga Park, California). HLA-DRB1 allele frequencies were compared with normal published controls (http://www.ncbi.nlm.nih.gov/projects/gv/mhc/ihwg.cgi dbMHC Europe cohort) and the published TINU cohort (n=18). - Results The authors included 28 subjects with uveitis and 14 with TIN. There was a significantly higher frequency of DRB1*0102 in the isolated uveitis cohort versus in normal controls (10.7% vs 0.6%, respectively, p<0.0001; RR 14.3 (6.9-29.8)). None of the nephritis patients showed this HLA subtype. Another association with HLA-DRB1*08 was seen in the isolated uveitis cohort with an allele frequency of 10.7% versus 2.7% in normal controls (p=0.0019; RR 4.0 (1.8-9.0)). In contrast, the HLA-DRB1*08 was not different from controls in the TINU cohort (allele frequency 2.8%, p=not significant). - Conclusion The incidence of HLA-DRB1*0102 is increased in sudden-onset bilateral anterior uveitis, as seen in patients with TINU. The same allele does not appear to occur in increased frequency in patients with isolated TIN. HLA DRB1*0102 might predispose to this subset of uveitis.