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| Verfasst von: | Cruz Vieira, José Ricardo da [VerfasserIn]  |
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| | Shah, Bhavin [VerfasserIn] |
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| | Dupraz, Sebastian [VerfasserIn] |
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| | Paredes Ugarte, Isidora B. [VerfasserIn] |
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| | Himmels, Patricia [VerfasserIn] |
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| | Schermann, Géza [VerfasserIn] |
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| | Adler, Heike [VerfasserIn] |
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| | Motta, Alessia [VerfasserIn] |
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| | Gärtner, Lea [VerfasserIn] |
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| | Navarro-Aragall, Ariadna [VerfasserIn] |
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| | Ioannou, Elena [VerfasserIn] |
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| | Dyukova, Elena [VerfasserIn] |
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| | Bonnavion, Remy [VerfasserIn] |
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| | Fischer, Andreas [VerfasserIn] |
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| | Bonanomi, Dario [VerfasserIn] |
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| | Bradke, Frank [VerfasserIn] |
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| | Ruhrberg, Christiana [VerfasserIn] |
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| | Ruiz de Almodóvar, Carmen [VerfasserIn] |
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| Titel: | Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development |
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| Verf.angabe: | José Ricardo Vieira, Bhavin Shah, Sebastian Dupraz, Isidora Paredes, Patricia Himmels, Géza Schermann, Heike Adler, Alessia Motta, Lea Gärtner, Ariadna Navarro-Aragall, Elena Ioannou, Elena Dyukova, Remy Bonnavion, Andreas Fischer, Dario Bonanomi, Frank Bradke, Christiana Ruhrberg, and Carmen Ruiz de Almodóvar |
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| E-Jahr: | 2022 |
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| Jahr: | December 21, 2022 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 02.01.2023 |
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| Titel Quelle: | Enthalten in: Neuron |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1988 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 110(2022), 24 vom: Dez., Seite 4074-4089 |
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| ISSN Quelle: | 1097-4199 |
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| Abstract: | How the vascular and neural compartment cooperate to achieve such a complex and highly specialized structure as the central nervous system is still unclear. Here, we reveal a crosstalk between motor neurons (MNs) and endothelial cells (ECs), necessary for the coordinated development of MNs. By analyzing cell-to-cell interaction profiles of the mouse developing spinal cord, we uncovered semaphorin 3C (Sema3C) and PlexinD1 as a communication axis between MNs and ECs. Using cell-specific knockout mice and in vitro assays, we demonstrate that removal of Sema3C in MNs, or its receptor PlexinD1 in ECs, results in premature and aberrant vascularization of MN columns. Those vascular defects impair MN axon exit from the spinal cord. Impaired PlexinD1 signaling in ECs also causes MN maturation defects at later stages. This study highlights the importance of a timely and spatially controlled communication between MNs and ECs for proper spinal cord development. |
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| DOI: | doi:10.1016/j.neuron.2022.12.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.neuron.2022.12.005 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0896627322010789 |
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| | DOI: https://doi.org/10.1016/j.neuron.2022.12.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | blood vessel |
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| | CNS vascularization |
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| | endothelial cell |
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| | motor neuron |
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| | neuro-vascular communication |
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| | neurodevelopment |
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| | PlexinD1 |
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| | Sema3C |
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| | spinal cord |
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| K10plus-PPN: | 1830157647 |
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| Verknüpfungen: | → Zeitschrift |
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Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development / Cruz Vieira, José Ricardo da [VerfasserIn]; December 21, 2022 (Online-Ressource)
