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| Verfasst von: | Zanotti, Andrea [VerfasserIn]  |
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| | Coelho, João P. L. [VerfasserIn] |
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| | Kaylani, Dinah [VerfasserIn] |
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| | Singh, Gurdeep [VerfasserIn] |
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| | Tauber, Marina [VerfasserIn] |
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| | Hitzenberger, Manuel [VerfasserIn] |
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| | Avci, Dönem [VerfasserIn] |
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| | Zacharias, Martin [VerfasserIn] |
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| | Russell, Robert B. [VerfasserIn] |
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| | Lemberg, Marius [VerfasserIn] |
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| | Feige, Matthias J. [VerfasserIn] |
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| Titel: | The human signal peptidase complex acts as a quality control enzyme for membrane proteins |
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| Verf.angabe: | Andrea Zanotti, João P. L. Coelho, Dinah Kaylani, Gurdeep Singh, Marina Tauber, Manuel Hitzenberger, Dönem Avci, Martin Zacharias, Robert B. Russell, Marius K. Lemberg and Matthias J. Feige |
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| E-Jahr: | 2022 |
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| Jahr: | 1 Dec 2022 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 27.02.2023 |
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| Titel Quelle: | Enthalten in: Science |
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| Ort Quelle: | Washington, DC : American Association for the Advancement of Science, 1880 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 378(2022), 6623, Seite 996-1000 |
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| ISSN Quelle: | 1095-9203 |
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| Abstract: | Cells need to detect and degrade faulty membrane proteins to maintain homeostasis. In this study, we identify a previously unknown function of the human signal peptidase complex (SPC)—the enzyme that removes endoplasmic reticulum (ER) signal peptides—as a membrane protein quality control factor. We show that the SPC cleaves membrane proteins that fail to correctly fold or assemble into their native complexes at otherwise hidden cleavage sites, which our study reveals to be abundant in the human membrane proteome. This posttranslocational cleavage synergizes with ER-associated degradation to sustain membrane protein homeostasis and contributes to cellular fitness. Cryptic SPC cleavage sites thus serve as predetermined breaking points that, when exposed, help to target misfolded or surplus proteins for degradation, thereby maintaining a healthy membrane proteome. |
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| DOI: | doi:10.1126/science.abo5672 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/science.abo5672 |
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| | Volltext: https://www.science.org/doi/10.1126/science.abo5672 |
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| | DOI: https://doi.org/10.1126/science.abo5672 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1837512353 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ human signal peptidase complex acts as a quality control enzyme for membrane proteins / Zanotti, Andrea [VerfasserIn]; 1 Dec 2022 (Online-Ressource)
