Cell-cycle regulation in embryonic stem cells

• Verfasst von: Koledova, Zuzana [VerfasserIn]
• Verfasst von: Krämer, Alwin [VerfasserIn]
• Verfasst von: Kafkova, Leona Raskova [VerfasserIn]
• Verfasst von: Divoky, Vladimir [VerfasserIn]
• Titel: Cell-cycle regulation in embryonic stem cells
• Titelzusatz: centrosomal decisions on self-renewal
• Verf.angabe: Zuzana Koledova, Alwin Krämer, Leona Raskova Kafkova, Vladimir Divoky
• E-Jahr: 2010
• Jahr: 1 Jul 2010
• Umfang: 16 S.
• Fussnoten: Gesehen am 21.03.2023
• Titel Quelle: Enthalten in: Stem Cells and Development
• Ort Quelle: Larchmont, NY : Liebert, 2004
• Jahr Quelle: 2010
• Band/Heft Quelle: 19(2010), 11 vom: Nov., Seite 1663-1678
• ISSN Quelle: 1557-8534
• DOI: doi:10.1089/scd.2010.0136
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1839653299

Abstract

Embryonic stem cells seem to have the intriguing capacity to divide indefinitely while retaining their pluripotency. This self-renewal is accomplished by specialized mechanisms of cell-cycle control. In the last few years, several studies have provided evidence for a direct link between cell-cycle regulation and cell-fate decisions in stem cells. In this review, we discuss the peculiarities of embryonic stem cell-cycle control mechanisms, implicate their involvement in cell-fate decisions, and distinguish centrosomes as important players in the self-renewal versus differentiation roulette.