Feasibility of training the dorsolateral prefrontal-striatal network by real-time fMRI neurofeedback

• Verfasst von: Weiss, Franziska [VerfasserIn]
• Verfasst von: Zhang, Jingying [VerfasserIn]
• Verfasst von: Aslan, Acelya [VerfasserIn]
• Verfasst von: Kirsch, Peter [VerfasserIn]
• Verfasst von: Gerchen, Martin Fungisai [VerfasserIn]
• Titel: Feasibility of training the dorsolateral prefrontal-striatal network by real-time fMRI neurofeedback
• Verf.angabe: Franziska Weiss, Jingying Zhang, Acelya Aslan, Peter Kirsch & Martin Fungisai Gerchen
• E-Jahr: 2022
• Jahr: 31 January 2022
• Umfang: 10 S.
• Fussnoten: Gesehen am 11.07.2023
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), Artikel-ID 1669, Seite 1-10
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-022-05675-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Functional magnetic resonance imaging
• Sach-SW: Psychology
• K10plus-PPN: 1852378638

Abstract

Real-time fMRI neurofeedback (rt-fMRI NF) is a promising non-invasive technique that enables volitional control of usually covert brain processes. While most rt-fMRI NF studies so far have demonstrated the ability of the method to evoke changes in brain activity and improve symptoms of mental disorders, a recently evolving field is network-based functional connectivity (FC) rt-fMRI NF. However, FC rt-fMRI NF has methodological challenges such as respirational artefacts that could potentially bias the training if not controlled. In this randomized, double-blind, yoke-controlled, pre-registered FC rt-fMRI NF study with healthy participants (N = 40) studied over three training days, we tested the feasibility of an FC rt-fMRI NF approach with online global signal regression (GSR) to control for physiological artefacts for up-regulation of connectivity in the dorsolateral prefrontal-striatal network. While our pre-registered null hypothesis significance tests failed to reach criterion, we estimated the FC training effect at a medium effect size at the end of the third training day after rigorous control of physiological artefacts in the offline data. This hints at the potential of FC rt-fMRI NF for the development of innovative transdiagnostic circuit-specific interventional approaches for mental disorders and the effect should now be confirmed in a well-powered study.