Lupine, a source of new as well as hidden food allergens

• Verfasst von: Jappe, Uta [VerfasserIn]
• Verfasst von: Vieths, Stefan [VerfasserIn]
• Titel: Lupine, a source of new as well as hidden food allergens
• Verf.angabe: Uta Jappe and Stefan Vieths
• E-Jahr: 2010
• Jahr: 07 January 2010
• Umfang: 14 S.
• Fussnoten: Gesehen am 18.07.2023
• Titel Quelle: Enthalten in: Molecular nutrition & food research
• Ort Quelle: Weinheim : Wiley-VCH, 2004
• Jahr Quelle: 2010
• Band/Heft Quelle: 54(2010), 1 vom: Jan., Seite 113-126
• ISSN Quelle: 1613-4133
• DOI: doi:10.1002/mnfr.200900365
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Conglutins
• Sach-SW: Flour
• Sach-SW: Food allergy
• Sach-SW: Legumes
• Sach-SW: Lupine
• K10plus-PPN: 1852945974

Abstract

The present review summarizes current knowledge about lupine allergy, potential sensitization routes, cross-reactions between lupine and other legumes, and the respective IgE-binding proteins. Since the 1990s, lupine flour is used as a substitute for or additive to other flours, mostly wheat flour, in several countries of the EU. In 1994, the first case of an immediate-type allergy after ingestion of lupine flour-containing pasta was reported. Since then, the number of published incidents following ingestion or inhalation of lupine flour is rising. So far, the Lupinus angustifolius β-conglutin has been designated as the allergen Lup an 1 by the International Union of Immunological Societies Allergen Nomenclature Subcommittee. Initially, publications focussed on the fact that peanut-allergic patients were at risk to develop anaphylaxis to lupine due to cross-reactivity between peanut and lupine. At present, however, the ratio between cases of pre-existing legume allergy (mostly peanut allergy) to de novo sensitization to lupine seed is nearly 1:1. Although in December 2006, lupine and products thereof were included in the EU foodstuff allergen list according to the Commission Directive 2006/142/EC amending Annex IIIA of Directive 2000/13/EC in order to prevent severe reactions caused by “hidden food allergens”, the majority of patients and medical personnel are still not aware of raw lupine seed as potentially dangerous food allergen.