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| Verfasst von: | Köppke, Julia [VerfasserIn]  |
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| | Keller, Luise-Elektra [VerfasserIn] |
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| | Stuck, Michelle [VerfasserIn] |
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| | Arnow, Nicolas D. [VerfasserIn] |
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| | Bannert, Norbert [VerfasserIn] |
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| | Döllinger, Jörg [VerfasserIn] |
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| | Cingöz, Oya [VerfasserIn] |
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| Titel: | Direct translation of incoming retroviral genomes |
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| Verf.angabe: | Julia Köppke, Luise-Elektra Keller, Michelle Stuck, Nicolas D. Arnow, Norbert Bannert, Joerg Doellinger & Oya Cingöz |
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| E-Jahr: | 2024 |
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| Jahr: | 05 January 2024 |
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| Umfang: | 12 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 11.03.2024 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 15(2024), Artikel-ID 299, Seite 1-12 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Viruses that carry a positive-sense, single-stranded (+ssRNA) RNA translate their genomes soon after entering the host cell to produce viral proteins, with the exception of retroviruses. A distinguishing feature of retroviruses is reverse transcription, where the +ssRNA genome serves as a template to synthesize a double-stranded DNA copy that subsequently integrates into the host genome. As retroviral RNAs are produced by the host cell transcriptional machinery and are largely indistinguishable from cellular mRNAs, we investigated the potential of incoming retroviral genomes to directly express proteins. Here we show through multiple, complementary methods that retroviral genomes are translated after entry. Our findings challenge the notion that retroviruses require reverse transcription to produce viral proteins. Synthesis of retroviral proteins in the absence of productive infection has significant implications for basic retrovirology, immune responses and gene therapy applications. |
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| DOI: | doi:10.1038/s41467-023-44501-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41467-023-44501-7 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-023-44501-7 |
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| | DOI: https://doi.org/10.1038/s41467-023-44501-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Infection |
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| | Retrovirus |
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| | Virology |
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| | Virus-host interactions |
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| K10plus-PPN: | 1883085705 |
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| Verknüpfungen: | → Zeitschrift |
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Direct translation of incoming retroviral genomes / Köppke, Julia [VerfasserIn]; 05 January 2024 (Online-Ressource)
