Cognitive Behavioral Therapy for late-life depression (CBTlate)

• Verfasst von: Dafsari, Forugh Salimi [VerfasserIn]
• Verfasst von: Bewernick, Bettina [VerfasserIn]
• Verfasst von: Böhringer, Sabine [VerfasserIn]
• Verfasst von: Domschke, Katharina [VerfasserIn]
• Verfasst von: Elsaeßer, Moritz [VerfasserIn]
• Verfasst von: Löbner, Margrit [VerfasserIn]
• Verfasst von: Luppa, Melanie [VerfasserIn]
• Verfasst von: Preis, Lukas [VerfasserIn]
• Verfasst von: Püsken, Julia [VerfasserIn]
• Verfasst von: Schmitt, Sandra [VerfasserIn]
• Verfasst von: Szekely, Andreea-Johanna [VerfasserIn]
• Verfasst von: Hellmich, Martin [VerfasserIn]
• Verfasst von: Müller, Wiebke [VerfasserIn]
• Verfasst von: Wagner, Michael [VerfasserIn]
• Verfasst von: Peters, Oliver [VerfasserIn]
• Verfasst von: Frölich, Lutz [VerfasserIn]
• Verfasst von: Riedel-Heller, Steffi Gerlinde [VerfasserIn]
• Verfasst von: Schramm, Elisabeth [VerfasserIn]
• Verfasst von: Hautzinger, Martin [VerfasserIn]
• Verfasst von: Jessen, Frank [VerfasserIn]
• Titel: Cognitive Behavioral Therapy for late-life depression (CBTlate)
• Titelzusatz: results of a multicenter, randomized, observer-blinded, controlled trial
• Verf.angabe: Forugh S. Dafsari, Bettina Bewernick, Sabine Böhringer, Katharina Domschke, Moritz Elsaesser, Margrit Löbner, Melanie Luppa, Lukas Preis, Julia Püsken, Sandra Schmitt, Andreea-Johanna Szekely, Martin Hellmich, Wiebke Müller, Michael Wagner, Oliver Peters, Lutz Frölich, Steffi Riedel-Heller, Elisabeth Schramm, Martin Hautzinger, Frank Jessen
• E-Jahr: 2023
• Jahr: June 2023
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: June 27 2023 ; Gesehen am 29.07.2024
• Titel Quelle: Enthalten in: Psychotherapy and psychosomatics
• Ort Quelle: Basel : Karger, 1965
• Jahr Quelle: 2023
• Band/Heft Quelle: 92(2023), 3, Seite 180-192
• ISSN Quelle: 1423-0348
• DOI: doi:10.1159/000529445
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 189674432X

Abstract

Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. Methods: In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. Results: Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. Conclusions: Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.