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| Verfasst von: | Saenz, Ernesto [VerfasserIn]  |
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| | Montagut, Nathally Espinosa [VerfasserIn] |
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| | Wang, Baohong [VerfasserIn] |
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| | Stein-Thöringer, Christoph [VerfasserIn] |
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| | Wang, Kaicen [VerfasserIn] |
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| | Weng, Honglei [VerfasserIn] |
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| | Ebert, Matthias [VerfasserIn] |
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| | Schneider, Kai Markus [VerfasserIn] |
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| | Li, Lanjuan [VerfasserIn] |
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| | Teufel, Andreas [VerfasserIn] |
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| Titel: | Manipulating the gut microbiome to alleviate steatotic liver disease |
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| Titelzusatz: | current progress and challenges |
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| Verf.angabe: | Ernesto Saenz, Nathally Espinosa Montagut, Baohong Wang, Christoph Stein-Thöringer, Kaicen Wang, Honglei Weng, Matthias Ebert, Kai Markus Schneider, Lanjuan Li, Andreas Teufel |
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| E-Jahr: | 2024 |
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| Jahr: | September 2024 |
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| Umfang: | 10 S. |
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| Fussnoten: | Online veröffentlicht: 31. Mai 2024, Artikelversion: 13. September 2024 ; Gesehen am 23.10.2024 |
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| Titel Quelle: | Enthalten in: Engineering |
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| Ort Quelle: | Beijing : Engineering Sciences Press., 2015 |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 40(2024), Seite 51-60 |
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| ISSN Quelle: | 2096-0026 |
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| Abstract: | The prevalence of metabolic-dysfunction-associated steatotic liver disease (MASLD) is alarmingly high; it is estimated to affect up to a quarter of the global population, making it the most common liver disorder worldwide. MASLD is characterized by excessive hepatic fat accumulation and is commonly associated with comorbidities such as obesity, dyslipidemia, and insulin resistance; however, it can also manifest in lean individuals. Therefore, it is crucial to develop effective therapies for this complex condition. Currently, there are no approved medications for MASLD treatment, so there is a pressing need to investigate alternative approaches. Extensive research has characterized MASLD as a multifaceted disease, frequently linked to metabolic disorders that stem from dietary habits. Evidence suggests that changes in the gut microbiome play a fundamental role in the development and progression of MASLD from simple steatosis to steatohepatitis and even hepatocellular carcinoma (HCC). In this review, we critically examine the literature on the emerging field of gut-microbiota-based therapies for MASLD and metabolic-dysfunction-associated steatohepatitis (MASH), including interventions such as fecal microbiota transplantation (FMT), probiotics, prebiotics, short-chain fatty acids, antibiotics, metabolic pathway targeting, and immune checkpoint kinase blockade. |
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| DOI: | doi:10.1016/j.eng.2024.03.019 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.eng.2024.03.019 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2095809924002686 |
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| | DOI: https://doi.org/10.1016/j.eng.2024.03.019 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Fatty liver |
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| | Fecal microbiota transplantation |
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| | Metabolic-dysfunction-associated steatotic liver disease |
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| | Microbiome |
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| K10plus-PPN: | 1906632774 |
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| Verknüpfungen: | → Zeitschrift |
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Manipulating the gut microbiome to alleviate steatotic liver disease / Saenz, Ernesto [VerfasserIn]; September 2024 (Online-Ressource)
