Pusch, Stefan PD Dr. rer. nat.Universität HeidelbergHeidelberg
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Publications in heiBIB
- Phillips, Emma: PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma / Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina… , 17 September 2022. - 12 S.
In: Oncogenesis, ISSN 2157-9024. 11(2022), 1, Seite 1-12
DOI: 10.1038/s41389-022-00433-3
- Plöger, Carolin: STAT1 and STAT3 exhibit a crosstalk and are associated with increased inflammation in hepatocellular carcinoma / Carolin Ploeger, Johannes Schreck, Thorben Huth, Angelika Fraas, Thomas Albrecht, Alphonse Charbel, … , 23 February 2022. - 16 S.
In: Cancers, ISSN 2072-6694. 14(2022), 5, Artikel-ID 1154
DOI: 10.3390/cancers14051154
- Kilian, Michael: T-cell receptor therapy targeting mutant capicua transcriptional repressor in experimental gliomas / Michael Kilian, Mirco Friedrich, Khwab Sanghvi, Edward Green, Stefan Pusch, Daisuke Kawauchi, Martin… , 15 January 2022. - 12 S.
In: Clinical cancer research, ISSN 1557-3265. 28(2022), 2 vom: Jan., Seite 378-389
DOI: 10.1158/1078-0432.CCR-21-1881
- Martija, Antoni Andreu: The multifunctional role of EMP3 in the regulation of membrane receptors associated with IDH-wild-type glioblastoma / Antoni Andreu Martija and Stefan Pusch, 17 May 2021. - 17 S.
In: International journal of molecular sciences, ISSN 1422-0067. 22(2021), 10, Artikel-ID 5261, Seite 1-17
DOI: 10.3390/ijms22105261
- Pusch, Stefan: Funktionelle Analyse tumorspezifischer Mutationen der Isocitrat-Dehydrogenase und daraus entwachsene diagnostische und therapeutische Ansätze / vorgelegt von Dr. rer. nat. Stefan René Pusch. -
Heidelberg, 2021. - 102 Seiten : Illustrationen, Diagramme
- Luiken, Sarah: NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis / Sarah Luiken, Angelika Fraas, Matthias Bieg, Raisatun Sugiyanto, Benjamin Goeppert, Stephan Singer, … , 13 February 2020. - 17 S.
In: Oncogene, ISSN 1476-5594. 39(2020), 15, Seite 3128-3144
DOI: 10.1038/s41388-020-1198-3
- Plöger, Carolin: Prohibitin, STAT3 and SH2D4A physically and functionally interact in tumor cell mitochondria / Carolin Ploeger, Thorben Huth, Raisatun Nisa Sugiyanto, Stefan Pusch, Benjamin Goeppert, Stephan Sin… , 30 November 2020. - 14 S.
In: Cell death & disease, ISSN 2041-4889. 11(2020), 11, Artikel-ID 1023, Seite 1-14
DOI: 10.1038/s41419-020-03220-3
- Usta, Diren: A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells / Diren Usta, Romain Sigaud, Juliane L. Buhl, Florian Selt, Viktoria Marquardt, David Pauck, Jennifer … , May 25, 2020. - 14 S.
In: Molecular cancer therapeutics, ISSN 1538-8514. 19(2020), 8, Seite 1737-1750
DOI: 10.1158/1535-7163.MCT-19-1021
- Dao Trong, Huy Philip: Large-scale drug screening in patient-derived IDHmut glioma stem cells identifies several efficient drugs among FDA-approved antineoplastic agents / Philip Dao Trong, Gerhard Jungwirth, Tao Yu, Stefan Pusch, Andreas Unterberg, Christel Herold-Mende … , 3 June 2020
In: Cells, ISSN 2073-4409. 9(2020,6) Artikel-Nummer 1389, 15 Seiten
DOI: 10.3390/cells9061389
- Ventura Ferreira, Mónica Sofia: Alternative lengthening of telomeres is the major telomere maintenance mechanism in astrocytoma with isocitrate dehydrogenase 1 mutation / Monica Sofia Ventura Ferreira, Mia Dahl Sørensen, Stefan Pusch, Dagmar Beier, Anne-Sophie Bouillon, … , 20 January 2020. - 14 S. : Illustrationen
In: Journal of neuro-oncology, ISSN 1573-7373. 147(2020), 1, Seite 1-14
DOI: 10.1007/s11060-020-03394-y
- Yang, Lijun: Identification of new inhibitors of mutant isocitrate dehydrogenase 2 through molecular similarity-based virtual screening / Lijun Yang, Stefan Pusch, Victoria Jennings, Tianfang Ma, Qihua Zhu, Yungen Xu, Andreas Von Deimling… , 2019. - 7 S.
In: Letters in drug design & discovery, ISSN 1875-628X. 16(2019), 8, Seite 861-867
DOI: 10.2174/1570180815666180808094432
- Zhang, Ying: Mutant IDH sensitizes gliomas to endoplasmic reticulum stress and triggers apoptosis via miR-183-mediated inhibition of semaphorin 3E / Ying Zhang, Stefan Pusch, James Innes, Kastytis Sidlauskas, Matthew Ellis, Joanne Lau, Tedani El-Has… , August 7, 2019. - 14 S.
In: Cancer research, ISSN 1538-7445. 79(2019), 19, Seite 4994-5007
DOI: 10.1158/0008-5472.CAN-19-0054
- Drucker, Elisabeth: Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer / Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, E… , 29 November 2019. - 14 S.
In: Cell communication and signaling, ISSN 1478-811X. 17(2019,1) Artikel-Nummer 159, 14 Seiten
DOI: 10.1186/s12964-019-0456-x
- Wirthschaft, Peter: RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas / Peter Wirthschaft, Julia Bode, Himanshu Soni, Fabio Dietrich, Thomas Krüwel, Bernd Fischer, Christia… , 2019. - 19 S.
In: Acta neuropathologica, ISSN 1432-0533. 138(2019), 2, Seite 275-293
DOI: 10.1007/s00401-019-02021-z
- Christians, Arne: Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation / Arne Christians, Eric Poisel, Christian Hartmann, Andreas von Deimling, Stefan Pusch, 7 Jan 2019. - 13 S.
In: International journal of cancer, ISSN 1097-0215. 145(2019), 2, Seite 461-473
DOI: 10.1002/ijc.32107
- Hou, Yanghao: Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA / Yanghao Hou, Jorge Pinheiro, Felix Sahm, David E. Reuss, Daniel Schrimpf, Damian Stichel, Belén Casa… , 13 February 2019. - 10 S.
In: Acta neuropathologica, ISSN 1432-0533. 137(2019), 5, Seite 837-846
DOI: 10.1007/s00401-019-01969-2
- Goeppert, Benjamin: Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p / Benjamin Goeppert, Felicia Truckenmueller, Alessandro Ori, Valerie Fritz, Thomas Albrecht, Angelika … , 18 March 2019. - 13 S.
In: Scientific reports, ISSN 2045-2322. 9(2019) Artikel-Nummer 4796, 13 Seiten
DOI: 10.1038/s41598-019-40857-3
- Buhl, Juliane: The senescence-associated secretory phenotype mediates oncogene-induced senescence in pediatric pilocytic astrocytoma / Juliane L. Buhl, Florian Selt, Thomas Hielscher, Romain Guiho, Jonas Ecker, Felix Sahm, Johannes Rid… , 15 March 2019. - 16 S.
In: Clinical cancer research, ISSN 1557-3265. 25(2019), 6, Seite 1851-1866
DOI: 10.1158/1078-0432.CCR-18-1965
- Ma, Tianfang: Inhibitors of mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) : an update and perspective / Tianfang Ma, Fangxia Zou, Stefan Pusch, Yungen Xu, Andreas von Deimling, and Xiaoming Zha, May 31, 2018. - 23 S. : Illustrationen
In: Journal of medicinal chemistry, ISSN 1520-4804. 61(2018), 20, Seite 8981-9003
DOI: 10.1021/acs.jmedchem.8b00159
- Dao Trong, Huy Philip: Identification of a prognostic hypoxia-associated gene set in IDH-mutant glioma / Philip Dao Trong, Saskia Rösch, Heimo Mairbäurl, Stefan Pusch, Andreas Unterberg, Christel Herold-Me… , 25 September 2018. - 14 S.
In: International journal of molecular sciences, ISSN 1422-0067. 19(2108,10) Artikel-Nummer 2903, 14 Seiten
DOI: 10.3390/ijms19102903
- Berberich, Anne: Targeting resistance against the MDM2 inhibitor RG7388 in glioblastoma cells by the MEK inhibitor trametinib / Anne Berberich, Tobias Kessler, Carina M. Thomé, Stefan Pusch, Thomas Hielscher, Felix Sahm, Iris Oe… , 2019. - 13 S.
In: Clinical cancer research, ISSN 1557-3265. 25(2019), 1, Seite 253-265
DOI: 10.1158/1078-0432.CCR-18-1580
- Bunse, Lukas: Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate / Lukas Bunse, Stefan Pusch, Theresa Bunse, Felix Sahm, Khwab Sanghvi, Mirco Friedrich, Dalia Alansary… , 09 July 2018. - 12 S.
In: Nature medicine, ISSN 1546-170X. 24(2018), Seite 1192-1203
DOI: 10.1038/s41591-018-0095-6
- Zou, Fangxia: Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening / Fangxia Zou, Stefan Pusch, Jie Hua, Tianfang Ma, Lijun Yang, Qihua Zhu, Yungen Xu, Yueqing Gu, Andre… , 2018. - 6 S.
In: Bioorganic & medicinal chemistry letters, ISSN 1464-3405. 28(2018), 3, Seite 388-393
DOI: 10.1016/j.bmcl.2017.12.030
- Ma, Tianfang: Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1 / Tianfang Ma, Fangxia Zou, Stefan Pusch, Lijun Yang, Qihua Zhu, Yungen Xu, Yueqing Gu, Andreas von De… . - 9 S.
In: Bioorganic & medicinal chemistry, ISSN 1464-3391. 25(2017), 24, S. 6379-6387
DOI: 10.1016/j.bmc.2017.10.009
- Pusch, Stefan: Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo / Stefan Pusch, Sonja Krausert, Viktoria Fischer, Jörg Balss, Martina Ott, Daniel Schrimpf, David Capp… . - 16 S.
In: Acta neuropathologica, ISSN 1432-0533. 133(2017), 4, S. 629-644
DOI: 10.1007/s00401-017-1677-y
- Chaturvedi, Anuhar: Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo / A. Chaturvedi, L. Herbst, S. Pusch, L. Klett, R. Goparaju, D. Stichel, S. Kaulfuss, O. Panknin, K. Z… , 24 February 2017. - 9 S.
In: Leukemia, ISSN 1476-5551. 31(2017), 10, Seite 2020-2028
DOI: 10.1038/leu.2017.46
- Zou, Fangxia: Identification of a novel selective inhibitor of mutant isocitrate dehydrogenase 1 at allosteric site by docking-based virtual screening / Fangxia Zou, Stefan Pusch, Jessica Eisel, Tianfang Ma, Qihua Zhu, Dawei Deng, Yueqing Gu, Yungen Xu,… , 26 Sep 2016. - 8 S.
In: RSC Advances, ISSN 2046-2069. 6(2016), 99, Seite 96735-96742
DOI: 10.1039/C6RA21617J
- Plöger, Carolin: Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma / Carolin Ploeger, Nina Waldburger, Angelika Fraas, Benjamin Goeppert, Stefan Pusch, Kai Breuhahn, Xin… . - 15 S.
In: Hepatology, ISSN 1527-3350. 64(2016), 3, S. 828-842
DOI: 10.1002/hep.28684
- Balß, Jörg: Pretreatment d -2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia / J. Balss, C. Thiede, T. Bochtler, J.G. Okun, M. Saadati, A. Benner, S. Pusch, G. Ehninger, M. Schaic… , 2016. - 7 S.
In: Leukemia, ISSN 1476-5551. 30(2016), 4, Seite 782-788
DOI: 10.1038/leu.2015.317
- Ott, Martina: Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway / Martina Ott, Ulrike M. Litzenburger, Katharina J. Rauschenbach, Lukas Bunse, Katharina Ochs, Felix S… , January 2015. - 13 S.
In: Glia, ISSN 1098-1136. 63(2015), 1, Seite 78-90
DOI: 10.1002/glia.22734
- Osswald, Matthias: Brain tumour cells interconnect to a functional and resistant network / Matthias Osswald, Erik Jung, Felix Sahm, Gergely Solecki, Varun Venkataramani, Jonas Blaes, Sophie W… , 2015. - 19 S.
In: Nature, ISSN 1476-4687. 528(2015), 7580, Seite 93-8
DOI: 10.1038/nature16071
- Bunse, Lukas: Proximity ligation assay evaluates IDH1 R132H presentation in gliomas / Lukas Bunse, Theresa Schumacher, Felix Sahm, Stefan Pusch, Iris Oezen, Katharina Rauschenbach, Marin… , 2015. - 14 S.
In: The journal of clinical investigation, ISSN 1558-8238. 125(2015), 2, Seite 593-606
DOI: 10.1172/JCI77780
- Birner, Peter: Mutant IDH1 inhibits PI3K/Akt signaling in human glioma / Peter Birner, MD, Stefan Pusch, PhD, Christo Christov, MD, Stiliana Mihaylova, MD, Kalina Toumangelo… , April 25, 2014. - 8 S.
In: Cancer, ISSN 1097-0142. 120(2014), 16, Seite 2440-2447
DOI: 10.1002/cncr.28732
- Bunse, Theresa: Mutant IDH1R132H bears a mutation-specific CD4 T cell epitope suitable for vaccination of human CNS tumors / Theresa Schumacher, Lukas Bunse, Stefan Pusch, Felix Sahm, Andreas von Deimling, Wolfgang Wick, Mich… , 15 October 2014. - 1 S.
In: Journal of neuroimmunology, ISSN 1872-8421. 275(2014,1/2) Artikel-Nummer 501, 1 Seite
DOI: 10.1016/j.jneuroim.2014.08.104
- Bunse, Lukas: In situ proximity ligation assay to evaluate presentation of a mutated CD4 epitope in human glioma tissue / Lukas Bunse, Theresa Schumacher, Felix Sahm, Stefan Pusch, Iris Oezen, Andreas von Deimling, Wolfgan… , 15 October 2014. - 1 S.
In: Journal of neuroimmunology, ISSN 1872-8421. 275(2014,1/2) Artikel-Nummer 256, 1 Seite
DOI: 10.1016/j.jneuroim.2014.08.096
- Reuss, David: Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations / David E. Reuss, Rosario M. Piro, David T.W. Jones, Matthias Simon, Ralf Ketter, Marcel Kool, Albert … , 12 February 2013. - 8 S.
In: Acta neuropathologica, ISSN 1432-0533. 125(2013), 3, Seite 351-358
DOI: 10.1007/s00401-013-1093-x
- Mohrenz, Isabelle Vanessa: Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death / Isabelle Vanessa Mohrenz; Patrick Antonietti; Stefan Pusch; David Capper; Jörg Balss; Sophia Voigt; … , 26 June 2013. - 10 S. : Ill., graph. Darst.
In: Apoptosis, ISSN 1573-675X. 18(2013), 11, Seite 1416-1425
DOI: 10.1007/s10495-013-0877-8
- Schweizer, Leonille: Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein / Leonille Schweizer · Christian Koelsche · Felix Sahm · Rosario M. Piro · David Capper · David E. Reu… , 2013. - 8 S.
In: Acta neuropathologica, ISSN 1432-0533. 125(2013), 5, Seite 651-658
DOI: 10.1007/s00401-013-1117-6
- Navis, Anna C.: Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG / Anna C. Navis; Simone P. Niclou; Fred Fack; Daniel Stieber; Sanne van Lith; Kiek Verrijp; Alan Wrigh… . -
London: BioMed Central, 2013. - 1 Online-Ressource
- Balß, Jörg: Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate / Jörg Balss, Stefan Pusch, Ann-Christin Beck, Christel Herold-Mende, Alwin Krämer, Christian Thiede, … , 2 November 2012. - 9 S.
In: Acta neuropathologica, ISSN 1432-0533. 124(2012), 6, Seite 883-891
DOI: 10.1007/s00401-012-1060-y
- Sahm, Felix: CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas / Felix Sahm, Christian Koelsche, Jochen Meyer, Stefan Pusch, Kerstin Lindenberg, Wolf Mueller, Christ… , June 2012. - 7 S.
In: Acta neuropathologica, ISSN 1432-0533. 123(2012), 6, Seite 853-860
DOI: 10.1007/s00401-012-0993-5
- Capper, David: Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases / David Capper, Anna Sophie Berghoff, Manuel Magerle, Aysegül Ilhan, Adelheid Wöhrer, Monika Hackl, Jo… , February 2012. - 11 S.
In: Acta neuropathologica, ISSN 1432-0533. 123(2012), 2, Seite 223-233
DOI: 10.1007/s00401-011-0887-y
- Capper, David: Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody / David Capper, Matthias Preusser, Antje Habel, Felix Sahm, Ulrike Ackermann, Genevieve Schindler, Ste… , 03 June 2011. - 9 S.
In: Acta neuropathologica, ISSN 1432-0533. 122(2011), Seite 11-19
DOI: 10.1007/s00401-011-0841-z
- Brehmer, Stefanie: Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations / S. Brehmer, S. Pusch, K. Schmieder, A. von Deimling, C. Hartmann, 2011. - 3 S.
In: Neuropathology & applied neurobiology, ISSN 1365-2990. 37(2011), 3, Seite 330-332
DOI: 10.1111/j.1365-2990.2010.01114.x
- Sahm, Felix: Detection of 2-hydroxyglutarate in formalin-fixed paraffin-embedded glioma specimens by gas chromatography/mass spectrometry / Felix Sahm, David Capper, Stefan Pusch, Jörg Balss, Arend Koch, Claus‐Dieter Langhans, Jürgen G. Oku… . - 6 S.
In: Brain pathology, ISSN 1750-3639. 22(2012), 1, S. 26-31
DOI: 10.1111/j.1750-3639.2011.00506.x
- Capper, David: Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody / David Capper, Matthias Preusser, Antje Habel, Felix Sahm, Ulrike Ackermann, Genevieve Schindler, Ste… , 2011. - 9 S.
In: Acta neuropathologica, ISSN 0001-6322. 122(2011), Seite 11-19
- Meyer, Jochen: PCR- and restriction endonuclease-based detection of IDH1 mutations / Jochen Meyer; Stefan Pusch; Jörg Balss; David Capper; Wolf Mueller; Arne Christians; Christian Hartm… , 02 February 2010. - 3 S.
In: Brain pathology, ISSN 1750-3639. 20(2010), 2, Seite 298-300
DOI: 10.1111/j.1750-3639.2009.00327.x
- Pusch, Stefan: Interaktionsanalyse von CDKA : 1 und anderen Zellzyklusregulatoren aus Arabidopsis thaliana / vorgelegt von Stefan René Pusch. -
157 S., 2008. - Ill., graph. Darst.
- Pusch, Stefan: Interaktionsanalyse von CDKA;1 und anderen Zellzyklusregulatoren aus Arabidopsis thaliana / vorgelegt von Stefan René Pusch, 2008. - Online-Ressource (PDF-Datei: 158 S., 2972 KB)