heiBIB: Witt, Olaf

Witt, Olaf Prof. Dr. med.Universität HeidelbergHeidelberg

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Publications in heiBIB

Filippidou, Maria: Soft tissue undifferentiated sarcoma carrying a novel Onecut1::Nutm1 fusion : letter to the editor / Maria Filippidou, Stavros Glentis, Efthymia Rigatou, Philipp Sievers, Florian Selt, Efthymios Dimitr… , January 2025. - 4 S. : Illustrationen
In: Pediatric blood & cancer, ISSN 1545-5017. 72(2025), 1 vom: Jan., Artikel-ID e31427, Seite 1-4
DOI: 10.1002/pbc.31427
Okonechnikov, Konstantin: Oncogene aberrations drive medulloblastoma progression, not initiation / Konstantin Okonechnikov, Piyush Joshi, Verena Körber, Anne Rademacher, Michele Bortolomeazzi, Jan-Ph… , 07 May 2025. - 34 S.
In: Nature, ISSN 1476-4687. 642(2025), 8069, Seite 1062-1072
DOI: 10.1038/s41586-025-08973-5
Hansford, Jordan R.: Comments and controversies in oncology : the tribulations of trials developing ONC201 / Jordan R. Hansford, MBBS, MSc, Gauthier Bouche, MD, Vijay Ramaswamy, MD, PhD, Nada Jabado, MD, PhD, … , December 2024. - 5 S.
In: Journal of clinical oncology, ISSN 1527-7755. 42(2024), 35 vom: Dez., Seite 4126-4129
DOI: 10.1200/JCO.24.00709
Kocher, Daniela: Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines / Daniela Kocher, Lei Cao, Romain Guiho, Melanie Langhammer, Yun-Lu Lai, Pauline Becker, Hiba Hamdi, D… , 17 April 2024. - 16 S. : Illustrationen
In: Journal of neuro-oncology, ISSN 1573-7373. 168(2024), 2 vom: Juni, Seite 317-332
DOI: 10.1007/s11060-024-04672-9
Kelety, Tibor: Adaption of neurosurgical resection patterns for pediatric low-grade glioma spanning two decades - report from the German LGG-studies 1996-2018 / Tibor Kelety, Ulrich-Wilhelm Thomale, Daniela Kandels, Martin U. Schuhmann, Ahmed El Damaty, Jürgen … , Jun 2024. - 19 S. : Illustrationen
In: Cancer medicine, ISSN 2045-7634. 13(2024), 12 vom: Juni, Artikel-ID e7417, Seite 1-19
DOI: 10.1002/cam4.7417
Gorodezki, David: A multi-institutional series of a novel, recurrent TRIM24::MET fusion-driven infant-type hemispheric glioma reveals significant clinico-pathological heterogeneity / David Gorodezki, Jason Chiang, Angela N. Viaene, Philipp Sievers, Simone Schmid, Ursula Holzer, Fran… , 21 June 2024. - 10 S. : Illustrationen
In: Acta Neuropathologica Communications, ISSN 2051-5960. 12(2024) vom: Juni, Artikel-ID 101, Seite 1-10
DOI: 10.1186/s40478-024-01817-9
Müller, Sabine: Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma : guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group / Sabine Mueller, Jason Fangusaro, Arzu Onar Thomas, Thomas S Jacques, Pratiti Bandopadhayay, Peter de… , 2024
In: Neuro-Oncology, ISSN 1523-5866. 26(2024), 3 vom: März, Seite 407-416
DOI: 10.1093/neuonc/noad227
Seiboldt, Till: Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours / Till Seiboldt, Constantia Zeiser, Duy Nguyen, Simay Celikyürekli, Sonja Herter, Sara Najafi, Alexand… , 28 June 2024. - 15 S. : Illustrationen
In: British journal of cancer, ISSN 1532-1827. 131(2024), 4, Seite 763-777
DOI: 10.1038/s41416-024-02740-5
O’Hare, Patricia: Resistance, rebound, and recurrence regrowth patterns in pediatric low-grade glioma treated by MAPK inhibition : a modified Delphi approach to build international consensus-based definitions : international pediatric low-grade glioma coalition / Patricia O’Hare, Tabitha Cooney, Peter de Blank, David H. Gutmann, Mark Kieran, Till Milde, Jason Fa… , August 2024. - 10 S.
In: Neuro-Oncology, ISSN 1523-5866. 26(2024), 8 vom: Aug., Seite 1357-1366
DOI: 10.1093/neuonc/noae074
Tilburg, Cornelis M. van: LOGGIC/FIREFLY-2 : a phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration / Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault, Rene Schmidt, Amedeo A. Azizi, Ofe… , 30 January 2024. - 11 S. : Illustrationen
In: BMC cancer, ISSN 1471-2407. 24(2024), Artikel-ID 147, Seite 1-11
DOI: 10.1186/s12885-024-11820-x
Zeuner, Simon: Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells / Simon Zeuner, Johanna Vollmer, Romain Sigaud, Sina Oppermann, Heike Peterziel, Dina ElHarouni, Ina O… , 07 January 2024. - 14 S. : Illustrationen
In: Journal of neuro-oncology, ISSN 1573-7373. 166(2024), Seite 99-112
DOI: 10.1007/s11060-023-04526-w
Kilburn, Lindsay B.: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma : the phase 2 FIREFLY-1 trial / Lindsay B. Kilburn, Dong-Anh Khuong-Quang, Jordan R. Hansford, Daniel Landi, Jasper van der Lugt, Sa… , January 2024. - 11 S.
In: Nature medicine, ISSN 1546-170X. 30(2024), 1 vom: Jan., Seite 207-217
DOI: 10.1038/s41591-023-02668-y
Heipertz, Anna-Elisa: Outcome of children and adolescents with relapsed/refractory/progressive malignancies treated with molecularly informed targeted drugs in the pediatric precision oncology registry INFORM / Anna-Elisa Heipertz, MD, Kristian W. Pajtler, MD, Elke Pfaff, MD, Kathrin Schramm, Dr. rer. nat., Mi… , June 26, 2023. - 12 S. : Illustrationen
In: JCO precision oncology, ISSN 2473-4284. (2023), 7, Artikel-ID e2300015, Seite 1-12
DOI: 10.1200/PO.23.00015
Bouffet, Eric: Dabrafenib plus Trametinib in pediatric glioma with BRAF V600 mutations / Eric Bouffet, M.D., Jordan R. Hansford, M.B., B.S., Maria Luisa Garrè, M.D., Junichi Hara, M.D., Ph.… , September 21, 2023. - 13 S. : Illustrationen
In: The New England journal of medicine, ISSN 1533-4406. 389(2023), 12, Seite 1108-1120
DOI: 10.1056/NEJMoa2303815
Kolodziejczak, Anna: Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome / Anna S Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Mar… , December 2023. - 14 S.
In: Neuro-Oncology, ISSN 1523-5866. 25(2023), 12 vom: Dez., Seite 2273-2286
DOI: 10.1093/neuonc/noad114
Selt, Florian: Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T : evaluation of a modeling workflow / Florian Selt, Ahmed El Damaty, Martin U. Schuhmann, Romain Sigaud, Jonas Ecker, Philipp Sievers, Dan… , 24 November 2023. - 12 S. : Illustrationen
In: Journal of neuro-oncology, ISSN 1573-7373. 165(2023), 3 vom: Nov., Seite 467-478
DOI: 10.1007/s11060-023-04500-6
Vollmer, Johanna: Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells / Johanna Vollmer, Jonas Ecker, Thomas Hielscher, Gintvile Valinciute, Johannes Ridinger, Nora Jamalad… , 3 October 2023. - 16 S.
In: Journal of neuro-oncology, ISSN 1573-7373. 164(2023), 3, Seite 617-632
DOI: 10.1007/s11060-023-04445-w
Mynarek, Martin: Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts / Martin Mynarek, Denise Obrecht, Martin Sill, Dominik Sturm, Katja Kloth-Stachnau, Florian Selt, Jona… , 2 December 2022. - 16 S. : Illustrationen, Diagramme
In: Acta neuropathologica, ISSN 1432-0533. 145(2023), 1, Seite 97-112
DOI: 10.1007/s00401-022-02522-4
Sigaud, Romain: MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas / Romain Sigaud, Thomas K. Albert, Caroline Hess, Thomas Hielscher, Nadine Winkler, Daniela Kocher, Ca… , 27 July 2023. - 21 S.
In: Nature Communications, ISSN 2041-1723. 14(2023), Artikel-ID 4533, Seite 1-21
DOI: 10.1038/s41467-023-40235-8
Pant, Shubham: Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR) : an international, single-arm, phase 2 study / Shubham Pant, Martin Schuler, Gopa Iyer, Olaf Witt, Toshihiko Doi, Shukui Qin, Josep Tabernero, Davi… , August 2023. - 11 S. : Illustrationen
In: The lancet, ISSN 1474-5488. 24(2023), 8 vom: Aug., Seite 925-935
DOI: 10.1016/S1470-2045(23)00275-9
Rahmanzade, Ramin: Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics / Ramin Rahmanzade, Elke Pfaff, Rouzbeh Banan, Philipp Sievers, Abigail K. Suwala, Felix Hinz, Henri B… , 30 September 2023. - 4 S. : Illustrationen
In: Acta neuropathologica, ISSN 1432-0533. 146(2023), 6, Seite 853-856
DOI: 10.1007/s00401-023-02638-1
Milde, Till: Optimizing preclinical pediatric low-grade glioma models for meaningful clinical translation / Till Milde, Jason Fangusaro, Michael J Fisher, Cynthia Hawkins, Fausto J Rodriguez, Uri Tabori, Olaf… , November 2023. - 12 S. : Illustrationen
In: Neuro-Oncology, ISSN 1523-5866. 25(2023), 11 vom: Nov., Seite 1920-1931
DOI: 10.1093/neuonc/noad125
Marquardt, Viktoria: Tacedinaline (CI-994), a class I HDAC inhibitor, targets intrinsic tumor growth and leptomeningeal dissemination in MYC-driven medulloblastoma while making them susceptible to anti-CD47-induced macrophage phagocytosis via NF-kB-TGM2 driven tumor inflammation / Viktoria Marquardt, Johanna Theruvath, David Pauck, Daniel Picard, Nan Qin, Lena Blümel, Mara Maue, … , 2023. - 16 S. : Illustrationen
In: Journal for ImmunoTherapy of Cancer, ISSN 2051-1426. 11(2023), 1, Artikel-ID e005871, Seite 1-16
DOI: 10.1136/jitc-2022-005871
Ecker, Jonas: Corrigendum to ‘Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry’ [Eur J Cancer 180 (2023) 71-84] / Jonas Ecker, Florian Selt, Dominik Sturm, Martin Sill, Andrey Korshunov, Steffen Hirsch, David Cappe… , May 2023. - 2 S.
In: European journal of cancer, ISSN 1879-0852. 184(2023) vom: Mai, Seite 200-201
DOI: 10.1016/j.ejca.2023.02.024
Kuhlen, Michaela: Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma / Michaela Kuhlen, Mariola Monika Golas, Tina Schaller, Nicole Stadler, Felicitas Maier, Olaf Witt and… , 2023. - 6 S.
In: Hereditary cancer in clinical practice, ISSN 1897-4287. 21(2023), Artikel-ID 8, Seite 1-6
DOI: 10.1186/s13053-023-00254-4
Schmidt, Stephanie: Cerebellar mutism syndrome ater posterior fossa tumor surgery in children : a retrospective single-center study / Stephanie Schmidt, Edina Kovacs, Diren Usta, Rouven Behnisch, Felix Sahm, Daniel Haux, Olaf Witt, Ti… , May 2023. - 7 S.
In: World neurosurgery, ISSN 1878-8769. 173(2023) vom: Mai, Seite e622-e628
DOI: 10.1016/j.wneu.2023.02.117
Ecker, Jonas: Molecular diagnostics enables detection of actionable targets : the Pediatric Targeted Therapy 2.0 registry / Jonas Ecker, Florian Selt, Dominik Sturm, Martin Sill, Andrey Korshunov, Steffen Hirsch, David Cappe… , February 2023. - 14 S. : Illustrationen
In: European journal of cancer, ISSN 1879-0852. 180(2023) vom: Feb., Seite 71-84
DOI: 10.1016/j.ejca.2022.11.015
Sturm, Dominik: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology / Dominik Sturm, David Capper, Felipe Andreiuolo, Marco Gessi, Christian Kölsche, Annekathrin Reinhard… , 16 March 2023. - 10 S.
In: Nature medicine, ISSN 1546-170X. 29(2023), 4, Seite 917-926
DOI: 10.1038/s41591-023-02255-1
Thomale, Ulrich-Wilhelm: Long-term follow-up of surgical intervention pattern in pediatric low-grade gliomas : report from the German SIOP-LGG 2004 cohort / Ulrich-Wilhelm Thomale, Astrid K. Gnekow, Daniela Kandels, Brigitte Bison, Pablo Hernáiz Driever, Ol… , [September 2022]. - 14 S. : Diagramme
In: Journal of neurosurgery, ISSN 1933-0715. 30(2022), 3 vom: Sept., Seite 316-329
DOI: 10.3171/2022.6.PEDS22108
Pearson, Andrew D. J.: Paediatric Strategy Forum for medicinal product development in mitogen-activated protein kinase pathway inhibitors : ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration / Andrew DJ. Pearson, Carl Allen, Jason Fangusaro, Caroline Hutter, Olaf Witt, Susan Weiner, Gregory R… , 14 October 2022. - 23 S.
In: European journal of cancer, ISSN 1879-0852. 177(2022), Seite 120-142
DOI: 10.1016/j.ejca.2022.09.036
Peterziel, Heike: Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM / Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yann… , 27 December 2022. - 17 S.
In: npj precision oncology, ISSN 2397-768X. 6(2022), Artikel-ID 94, Seite 1-17
DOI: 10.1038/s41698-022-00335-y
Tsai, Jessica W.: FOXR2 Is an epigenetically regulated pan-cancer oncogene that activates ETS transcriptional circuits / Jessica W. Tsai, Paloma Cejas, Dayle K. Wang, Smruti Patel, David W. Wu, Phonepasong Arounleut, Xin … , September 02 2022. - 22 S.
In: Cancer research, ISSN 1538-7445. 82(2022), 17, Seite 2980-3001
DOI: 10.1158/0008-5472.CAN-22-0671
Dittes, Christine: Local and systemic therapy of recurrent medulloblastomas in children and adolescents : results of the P-HIT-REZ 2005 study / Christine Gaab, Jonas E. Adolph, Stephan Tippelt, Ruth Mikasch, Denise Obrecht, Martin Mynarek, Stef… , 18 January 2022. - 24 S.
In: Cancers, ISSN 2072-6694. 14(2022), 3, Artikel-ID 471, Seite 1-24
DOI: 10.3390/cancers14030471
Gatzweiler, Charlotte: Functional therapeutic target validation using pediatric zebrafish xenograft models / Charlotte Gatzweiler, Johannes Ridinger, Sonja Herter, Xenia F. Gerloff, Dina ElHarouni, Yannick Ber… , 8 February 2022. - 24 S.
In: Cancers, ISSN 2072-6694. 14(2022), 3, Artikel-ID 849, Seite 1-24
DOI: 10.3390/cancers14030849
Ameline, Baptiste: Overactivation of the IGF signalling pathway in osteosarcoma : a potential therapeutic target? / Baptiste Ameline, Michal Kovac, Michaela Nathrath, Maxim Barenboim, Olaf Witt, Andreas H Krieg and D… , March 2021. - 8 S.
In: The journal of pathology: clinical research, ISSN 2056-4538. 7(2021), 2 vom: März, Seite 165-172
DOI: 10.1002/cjp2.191
Sievers, Philipp: GOPC : ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types / Philipp Sievers, Damian Stichel, Martin Sill, Daniel Schrimpf, Dominik Sturm, Florian Selt, Jonas Ec… , 18 September 2021. - 5 S.
In: Acta neuropathologica, ISSN 1432-0533. 142(2021), 6, Seite 1065-1069
DOI: 10.1007/s00401-021-02369-1
Deng, Maximilian: Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B / Maximilian Y. Deng, Dominik Sturm, Elke Pfaff, Martin Sill, Damian Stichel, Gnana Prakash Balasubram… , 20 September 2021. - 11 S.
In: Nature Communications, ISSN 2041-1723. 12(2021), Artikel-ID 5530, Seite 1-11
DOI: 10.1038/s41467-021-25708-y
Barenboim, Maxim: DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma / Maxim Barenboim, Michal Kovac, Baptiste Ameline, David T. W. Jones, Olaf Witt, Stefan Bielack, Stefa… , November 11, 2021. - 24 S.
In: PLoS Computational Biology, ISSN 1553-7358. 17(2021), 11, Artikel-ID e1009562, Seite 1-24
DOI: 10.1371/journal.pcbi.1009562
Adolph, Jonas E.: Local and systemic therapy of recurrent ependymoma in children and adolescents : short- and long-term results of the E-HIT-REZ 2005 study / Jonas E. Adolph, Gudrun Fleischhack, Ruth Mikasch, Julia Zeller, Monika Warmuth-Metz, Brigitte Bison… , 2021. - 12 S.
In: Neuro-Oncology, ISSN 1523-5866. 23(2021), 6, Seite 1012-1023
DOI: 10.1093/neuonc/noaa276
Weusthof, Katharina: Neurocognitive outcomes in pediatric patients following brain irradiation / Katharina Weusthof, Peggy Lüttich, Sebastian Regnery, Laila König, Denise Bernhardt, Olaf Witt, Klau… , 15 July 2021. - 16 S.
In: Cancers, ISSN 2072-6694. 13(2021), 14, special issue, Artikel-ID 3538, Seite 1-16
DOI: 10.3390/cancers13143538
Müller, Michael: Combining APR-246 and HDAC-inhibitors : a novel targeted treatment option for neuroblastoma / Michael Müller, Lisa Rösch, Sara Najafi, Charlotte Gatzweiler, Johannes Ridinger, Xenia F. Gerloff, … , 5 September 2021. - 23 S.
In: Cancers, ISSN 2072-6694. 13(2021), 17, Artikel-ID 4476, Seite 1-23
DOI: 10.3390/cancers13174476
Vassal, Gilles: International consensus on minimum preclinical testing requirements for the development of innovative therapies for children and adolescents with cancer / Gilles Vassal, Peter J. Houghton, Stefan M. Pfister, Malcolm A. Smith, Huib N. Caron, Xiao-Nan Li, D… , June 9, 2021. - 7 S.
In: Molecular cancer therapeutics, ISSN 1538-8514. 20(2021), 8 vom: Aug., Seite 1462-1468
DOI: 10.1158/1535-7163.MCT-20-0394
Tilburg, Cornelis M. van: The pediatric precision oncology INFORM registry : clinical outcome and benefit for patients with very high-evidence targets / Cornelis M. van Tilburg, Elke Pfaff, Kristian W. Pajtler, Karin P. S. Langenberg, Petra Fiesel, Barb… , August 9, 2021. - 16 S.
In: Cancer discovery, ISSN 2159-8290. 11(2021), 11, Seite 2764-2779
DOI: 10.1158/2159-8290.CD-21-0094
Sievers, Philipp: A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR / Philipp Sievers, Martin Sill, Daniel Schrimpf, Damian Stichel, David E. Reuss, Dominik Sturm, Jürgen… , 2021. - 10 S.
In: Neuro-Oncology, ISSN 1523-5866. 23(2021), 1, Seite 34-43
DOI: 10.1093/neuonc/noaa251
Gnekow, Astrid K.: Doubling recruitment of pediatric low-grade Glioma within two decades does not change outcome : report from the german LGG studies / Astrid Katharina Gnekow, Daniela Kandels, Torsten Pietsch, Brigitte Bison, Monika Warmuth-Metz, Ulri… , 10. Mai 2021. - 16 S.
In: Klinische Pädiatrie, ISSN 1439-3824. 233(2021), 03, Seite 107-122
DOI: 10.1055/a-1471-5897
Körholz, Katharina: Broad-spectrum HDAC inhibitors promote autophagy through FOXO transcription factors in neuroblastoma / Katharina Körholz, Johannes Ridinger, Damir Krunic, Sara Najafi, Xenia F. Gerloff, Karen Frese, Benj… , 24 April 2021. - 18 S.
In: Cells, ISSN 2073-4409. 10(2021), 5, Artikel-ID 1001, Seite 1-18
DOI: 10.3390/cells10051001
Ecker, Jonas: Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma / Jonas Ecker, Venu Thatikonda, Gianluca Sigismondo, Florian Selt, Gintvile Valinciute, Ina Oehme, Car… , 2021. - 14 S.
In: Neuro-Oncology, ISSN 1523-5866. 23(2021), 2 vom: Feb., Seite 226-239
DOI: 10.1093/neuonc/noaa191
Pfaff, Elke: NTRK alterations in pediatric high-risk malignancies identified through European clinical sequencing programs constitute promising drug targets / Elke Pfaff, Tiphaine Adam de Beaumais, Antonin Marchais, Cornelis M. van Tilburg, Mirjam Blattner-Jo… , February 26, 2021. - 5 S.
In: JCO precision oncology, ISSN 2473-4284. 5(2021), Seite 450-454
DOI: 10.1200/PO.20.00417
Kölsche, Christian: Sarcoma classification by DNA methylation profiling / Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam… , 21 January 2021. - 10 S.
In: Nature Communications, ISSN 2041-1723. 12(2021), Artikel-ID 498, Seite 1-10
DOI: 10.1038/s41467-020-20603-4
Stainczyk, Sabine: Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome / Sabine A. Hartlieb, Lina Sieverling, Michal Nadler-Holly, Matthias Ziehm, Umut H. Toprak, Carl Herrm… , 24 February 2021. - 18 S.
In: Nature Communications, ISSN 2041-1723. 12(2021), Artikel-ID 1269, Seite 1-18
DOI: 10.1038/s41467-021-21247-8
Selt, Florian: Response to trametinib treatment in progressive pediatric low-grade glioma patients / Florian Selt, Cornelis M. van Tilburg, Brigitte Bison, Philipp Sievers, Inga Harting, Jonas Ecker, K… , 7 October 2020. - 12 S. : Illustrationen
In: Journal of neuro-oncology, ISSN 1573-7373. 149(2020) vom: Sept., Seite 499-510
DOI: 10.1007/s11060-020-03640-3
Tilburg, Cornelis M. van: INFORM2 NivEnt : the first trial of the INFORM2 biomarker driven phase I/II trial series : the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies / Cornelis M. van Tilburg, Ruth Witt, Melanie Heiss, Kristian W. Pajtler, Christoph Plass, Isabel Posc… , 05 June 2020. - 12 S.
In: BMC cancer, ISSN 1471-2407. 20(2020) vom: Juni, Artikel-ID 523, Seite 1-12
DOI: 10.1186/s12885-020-07008-8
Wrobel, Jagoda: Rapid in vivo validation of HDAC inhibitor-based treatments in neuroblastoma zebrafish xenografts / Jagoda K. Wrobel, Sara Najafi, Simay Ayhan, Charlotte Gatzweiler, Damir Krunic, Johannes Ridinger, T… , 27 October 2020
In: Pharmaceuticals, ISSN 1424-8247. 13(2020,11) Artikel-Nummer 345, 19 Seiten
DOI: 10.3390/ph13110345
Usta, Diren: A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells / Diren Usta, Romain Sigaud, Juliane L. Buhl, Florian Selt, Viktoria Marquardt, David Pauck, Jennifer … , May 25, 2020. - 14 S.
In: Molecular cancer therapeutics, ISSN 1538-8514. 19(2020), 8, Seite 1737-1750
DOI: 10.1158/1535-7163.MCT-19-1021
Clarke, Matthew: Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes / Matthew Clarke, Alan Mackay, Britta Ismer, Jessica C. Pickles, Ruth G. Tatevossian, Scott Newman, Te… , April 1, 2020. - 22 S.
In: Cancer discovery, ISSN 2159-8290. 10(2020), 7, Seite 942-963
DOI: 10.1158/2159-8290.CD-19-1030
Fangusaro, Jason R.: Response assessment in paediatric low-grade glioma : recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group : imaging guidelines for paediatric brain tumours 1 / Jason Fangusaro, Olaf Witt, Pablo Hernáiz Driever, Asim K Bag, Peter de Blank, Nadja Kadom, Lindsay … , 2 June 2020. - 12 S.
In: The lancet, ISSN 1474-5488. 21(2020), 6, Seite e305-e316
DOI: 10.1016/S1470-2045(20)30064-4
Waszak, Sebastian Martin: Germline elongator mutations in Sonic Hedgehog medulloblastoma / Sebastian M. Waszak, Robinson Giles W, Brian L. Gudenas, Kyle S. Smith, Antoine Forget, Marija Kojic… , 01 April 2020. - 21 S.
In: Nature, ISSN 1476-4687. 580(2020), 7803, Seite 396-401
DOI: 10.1038/s41586-020-2164-5
Hong, David S.: Larotrectinib in patients with TRK fusion-positive solid tumours : a pooled analysis of three phase 1/2 clinical trials / David S Hong, Steven G DuBois, Shivaani Kummar, Anna F Farago, Catherine M Albert, Kristoffer S Rohr… , [April 2020]. - 10 S. : Diagramme
In: The lancet, ISSN 1474-5488. 21(2020), 4, Seite 531-540
DOI: 10.1016/S1470-2045(19)30856-3
Deng, Maximilian: Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14 / M.Y. Deng, M. Sill, D. Sturm, D. Stichel, H. Witt, J. Ecker, A. Wittmann, J. Schittenhelm, M. Ebinge… , 2020
In: Neuropathology & applied neurobiology, ISSN 1365-2990. 46(2020), 5, Seite 422-430
DOI: 10.1111/nan.12590
Tilburg, Cornelis M. van: Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia / Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-… , 10 December 2019. - 15 S.
In: Clinical epigenetics, ISSN 1868-7083. 11(2019) Artikel-Nummer 188, 15 Seiten
DOI: 10.1186/s13148-019-0775-1
Holzapfel, Johannes: Favorable prognosis in pediatric brainstem low-grade glioma : Report from the German SIOP-LGG 2004 cohort / Johannes Holzapfel, Daniela Kandels, René Schmidt, Torsten Pietsch, Monika Warmuth‐Metz, Brigitte Bi… , 2020. - 12 S.
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Brockmann, Markus: Small molecule inhibitors of Aurora-A induce proteasomal degradation of N-Myc in childhood neuroblastoma / Markus Brockmann, Evon Poon, Teeara Berry, Anne Carstensen, Hedwig E. Deubzer, Lukas Rycak, Yann Jam… , June 20, 2013. - 15 S.
In: Cancer cell, ISSN 1878-3686. 24(2013), 1, Seite 75-89
DOI: 10.1016/j.ccr.2013.05.005
Bender, Sebastian: Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas / Sebastian Bender, Yujie Tang, Anders M. Lindroth, Volker Hovestadt, David T.W. Jones, Marcel Kool, M… , October 31, 2013. - 13 S.
In: Cancer cell, ISSN 1878-3686. 24(2013), 5, Seite 660-672
DOI: 10.1016/j.ccr.2013.10.006
Oehme, Ina: Histone deacetylase 10 promotes autophagy-mediated cell survival / Ina Oehme, Jan-Peter Linke, Barbara C. Böck, Till Milde, Marco Lodrini, Bettina Hartenstein, Inga Wi… , 2013. - 10 S.
In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424. 110(2013), 28, Seite E2592-E2601
Franz, David N.: Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1) : a multicentre, randomised, placebo-controlled phase 3 trial / David Neal Franz, Elena Belousova, Steven Sparagana, E Martina Bebin, Michael Frost, Rachel Kuperman… , 2013. - 8 S.
In: The lancet. 381(2013), 9861, Seite 125-132
DOI: 10.1016/S0140-6736(12)61134-9
Jones, David T. W.: Dissecting the genomic complexity underlying medulloblastoma / David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae … , 2012. - 6 S.
In: Nature, ISSN 0028-0836. 488(2012), 7409 vom: 20. Juni, Seite 100-105
Milde, Till: HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment / Till Milde, Marco Lodrini, Larissa Savelyeva, Andrey Korshunov, Marcel Kool, Lena M. Brueckner, Andr… , December 2012. - 14 S.
In: Journal of neuro-oncology, ISSN 1573-7373. 110(2012), 3, Seite 335-348
DOI: 10.1007/s11060-012-0978-1
Milde, Till: Nestin expression identifies ependymoma patients with poor outcome / Till Milde, Thomas Hielscher, Hendrik Witt, Marcel Kool, Stephen C. Mack, Hedwig E. Deubzer, Ina Oeh… , 09 May 2012. - 13 S.
In: Brain pathology, ISSN 1750-3639. 22(2012), 6, Seite 848-860
DOI: 10.1111/j.1750-3639.2012.00600.x
Bai, Alfa H. C.: MicroRNA-182 promotes leptomeningeal spread of non-Sonic Hedgehog-medulloblastoma / Alfa H. C. Bai, Till Milde, Marc Remke, Claudio G. Rolli, Thomas Hielscher, Yoon-Jae Cho, Marcel Koo… , 2012. - 10 S.
In: Acta neuropathologica, ISSN 1432-0533. 123(2012), 4, Seite 529-538
DOI: 10.1007/s00401-011-0924-x
Combs, Stephanie: Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT) : establishment of workflow and initial clinical data / Stephanie E. Combs, Kerstin A. Kessel, Klaus Herfarth, Alexandra Jensen, Susanne Oertel, Claudia Bla… , 17 October 2012. - 9 S.
In: Radiation oncology, ISSN 1748-717X. 7(2012) Artikel-Nummer 170, 9 Seiten
DOI: 10.1186/1748-717X-7-170
Dovzhanskiy, Dmitriy I.: Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer / Dmitriy I. Dovzhanskiy, Stefanie M. Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathal… , 8 June 2012. - 9 S.
In: BMC cancer, ISSN 1471-2407. 12(2012) Artikel-Nummer 226, 9 Seiten
DOI: 10.1186/1471-2407-12-226
Witt, Olaf: Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia / O. Witt, T. Milde, H.E. Deubzer, I. Oehme, R. Witt, A. Kulozik, A. Eisenmenger, U. Abel, I. Karapana… , 2012. - 6 S.
In: Klinische Pädiatrie, ISSN 1439-3824. 224(2012), 06, Seite 398-403
DOI: 10.1055/s-0032-1323692
Jones, David T. W.: Dissecting the genomic complexity underlying medulloblastoma / David T.W. Jones, Natalie Jäger, Marcel Kool, Thomas Zichner, Barbara Hutter, Marc Sultan, Yoon-Jae … , 25 July 2012. - 6 S.
In: Nature, ISSN 1476-4687. 488(2012), 7409, Seite 100-105
DOI: 10.1038/nature11284
Schwartzentruber, Jeremy: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma / Jeremy Schwartzentruber, Andrey Korshunov, Xiao-Yang Liu, David T.W. Jones, Elke Pfaff, Karine Jacob… , 29 January 2012. - 6 S.
In: Nature, ISSN 1476-4687. 482(2012), 7384, Seite 226-231
DOI: 10.1038/nature10833
Rausch, Tobias: Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations / Tobias Rausch, David T.W. Jones, Marc Zapatka, Adrian M. Stütz, Thomas Zichner, Joachim Weischenfeld… , 19 January 2012. - 13 S.
In: Cell, ISSN 1097-4172. 148(2012), 1, Seite 59-71
DOI: 10.1016/j.cell.2011.12.013
Sturm, Dominik: Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma / Dominik Sturm; Hendrik Witt ... David T. W. Jones; Carolin Konermann; Elke Pfaff ... Sebastian Bende… , October 15, 2012. - 13 S.
In: Cancer cell, ISSN 1878-3686. 22(2012), 4, Seite 425-437
DOI: 10.1016/j.ccr.2012.08.024
Deubzer, Hedwig: HDAC11 is a novel drug target in carcinomas / Hedwig E. Deubzer, Marie C. Schier, Ina Oehme, Marco Lodrini, Bernard Haendler, Anette Sommer and Ol… , 2013. - 9 S.
In: International journal of cancer, ISSN 1097-0215. 132(2013), 9, Seite 2200-2208
DOI: 10.1002/ijc.27876
Pfaff, Elke: Reply to J.C. Lindsey et al / Elke Pfaff, Marc Remke, Dominik Sturm, Axel Benner, Hendrik Witt, Till Milde, André O. von Bueren, N… , February 28, 2011. - 2 S.
In: Journal of clinical oncology, ISSN 1527-7755. 29(2011), 12, Seite e348-e349
DOI: 10.1200/JCO.2010.34.1545
Witt, Hendrik: Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma / Hendrik Witt, Stephen C. Mack, Marina Ryzhova, Sebastian Bender, Martin Sill, Ruth Isserlin, Axel Be… , August 15, 2011. - 15 S.
In: Cancer cell, ISSN 1878-3686. 20(2011), 2, Seite 143-157
DOI: 10.1016/j.ccr.2011.07.007
Rieken, Stefan: Outcome and prognostic factors of radiation therapy for medulloblastoma / Stefan Rieken, Angela Mohr, Daniel Habermehl, Thomas Welzel, Katja Lindel, Olaf Witt, Andreas E. Kul… , 23 February 2011. - 7 S.
In: International journal of radiation oncology, biology, physics, ISSN 1879-355X. 81(2011), 3, Seite e7-e13
DOI: 10.1016/j.ijrobp.2010.12.042
Milde, Till: A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat / Till Milde, Susanne Kleber, Andrey Korshunov, Hendrik Witt, Thomas Hielscher, Philipp Koch, Hans-Geo… , 24 August 2011. - 14 S.
In: Acta neuropathologica, ISSN 1432-0533. 122(2011), 5, Artikel-ID 637, Seite 1-14
DOI: 10.1007/s00401-011-0866-3
Ley, Sebastian: Neuroblastoma imaging / S. Ley, J. Ley-Zaporozhan, P. Günther, H.E. Deubzer, O. Witt, J.-P. Schenk, 2011. - 9 S.
In: RöFo, ISSN 1438-9010. 183(2011), 03, Seite 217-225
DOI: 10.1055/s-0029-1245903
Gronych, Jan: An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice / Jan Gronych, Andrey Korshunov, Josephine Bageritz, Till Milde, Manfred Jugold, Dolores Hambardzumyan… , April 2011. - 5 S.
In: The journal of clinical investigation, ISSN 1558-8238. 121(2011), 4, Seite 1344-1348
DOI: 10.1172/JCI44656
Jacob, Karine: Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas / Karine Jacob, Dongh-Anh Quang-Khuong, David T.W. Jones, Hendrik Witt, Sally Lambert, Steffen Albrech… , July 17 2011. - 11 S.
In: Clinical cancer research, ISSN 1557-3265. 17(2011), 14, Seite 4650-4660
DOI: 10.1158/1078-0432.CCR-11-0127
Jones, David T. W.: MAPK pathway activation in pilocytic astrocytoma / David T.W. Jones, Jan Gronych, Peter Lichter, Olaf Witt, Stefan M. Pfister, 2012. - 13 S.
In: Cellular and molecular life sciences, ISSN 1420-9071. 69(2012), 11, Seite 1799-1811
DOI: 10.1007/s00018-011-0898-9
Rokes, Christopher Alan: Sorafenib plus valproic acid for infant spinal glioblastoma / Christopher Alan Rokes, MD, Mark Remke, MD, Nandita Guha-Thakurta, MD, Olaf Witt, MD, Andrey Korshun… , 2010. - 4 S.
In: Journal of pediatric hematology - oncology, ISSN 1536-3678. 32(2010), 6 vom: Aug., Seite 511-514
DOI: 10.1097/MPH.0b013e3181d74702
Rieken, Stefan: Outcome and prognostic factors of desmoplastic medulloblastoma treated within a multidisciplinary treatment concept / Stefan Rieken, Timo Gaiser, Angela Mohr, Thomas Welzel, Olaf Witt, Andreas E Kulozik, Wolfgang Wick,… , 23 August 2010. - 10 S.
In: BMC cancer, ISSN 1471-2407. 10(2010), Artikel-ID 450, Seite 1-10
DOI: 10.1186/1471-2407-10-450
Pfaff, Elke: TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma / Elke Pfaff, Marc Remke, Dominik Sturm, Axel Benner, Hendrik Witt, Till Milde, André O. von Bueren, A… , November 08, 2010. - 9 S.
In: Journal of clinical oncology, ISSN 1527-7755. 28(2010), 35 vom: Nov., Seite 5188-5196
DOI: 10.1200/JCO.2010.31.1670
Milde, Till: HDAC5 and HDAC9 in medulloblastoma : novel markers for risk stratification and role in tumor cell growth / Till Milde, Ina Oehme, Andrey Korshunov, Annette Kopp-Schneider, Marc Remke, Paul Northcott, Hedwig … , June 14 2010. - 13 S.
In: Clinical cancer research, ISSN 1557-3265. 16(2010), 12, Seite 3240-3252
DOI: 10.1158/1078-0432.CCR-10-0395
Korshunov, Andrey: Molecular staging of intracranial ependymoma in children and adults / Andrey Korshunov, Hendrik Witt, Thomas Hielscher, Axel Benner, Marc Remke, Marina Ryzhova, Till Mild… , June 1, 2010. - 9 S.
In: Journal of clinical oncology, ISSN 1527-7755. 28(2010), 19 vom: Juli, Seite 3182-3190
DOI: 10.1200/JCO.2009.27.3359
Korshunov, Andrey: Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes / Andrey Korshunov, Marc Remke, Marco Gessi, Marina Ryzhova, Thomas Hielscher, Hendrik Witt, Vivienne … , 21 April 2010. - 8 S.
In: Acta neuropathologica, ISSN 1432-0533. 120(2010), 2, Seite 253-260
DOI: 10.1007/s00401-010-0688-8
Lacroix, Jeannine: Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells / Jeannine Lacroix, Barbara Leuchs, Junwei Li, Georgi Hristov, Hedwig E. Deubzer, Andreas E. Kulozik, … , 25 June 2010. - 10 S.
In: International journal of cancer, ISSN 1097-0215. 127(2010), 5, Seite 1230-1239
DOI: 10.1002/ijc.25168
Lacroix, Jeannine: Therapeutic exploitation of oncolytic viruses in pediatric oncology / J. Lacroix, O. Witt, J.R. Schlehofer and J. Rommelaere, 2010. - 13 S.
In: Drugs of the future, ISSN 2013-0368. 35(2010), 12, Seite 1015-1027
DOI: 10.1358/dof.2010.035.012.1521419
Blattmann, Claudia: Enhancement of radiation response in osteosarcoma and rhabomyosarcoma cell lines by histone deacetylase inhibition / CLAUDIA BLATTMANN, M.D., SUSANNE OERTEL, M.D., VOLKER EHEMANN, PH.D., MARKUS THIEMANN, PH.D., PETER … , March 19, 2010. - 9 S.
In: International journal of radiation oncology, biology, physics, ISSN 1879-355X. 78(2010), 1, Seite 237-245
DOI: 10.1016/j.ijrobp.2010.03.010

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